Research progress of mitochondria in uveal melanoma
10.3980/j.issn.1672-5123.2026.4.08
- VernacularTitle:线粒体在葡萄膜黑色素瘤中的研究进展
- Author:
Xiqianru ZHANG
1
;
Ruifeng WANG
1
;
Rouqing WU
1
;
Yongqi LIU
1
;
Yuemei ZHANG
1
Author Information
1. The First School of Clinical Medicine, Lanzhou University;the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
uveal melanoma;
mitochondria;
mitophagy;
PI3K/AKT signaling pathway
- From:
International Eye Science
2026;26(4):600-604
- CountryChina
- Language:Chinese
-
Abstract:
Uveal melanoma(UM)is the most common primary intraocular malignancy in adults and arises predominantly from the choroid. Mitochondria, as essential organelles, not only fuel energy metabolism, but also orchestrate signal transduction and apoptosis. Recent studies have progressively uncovered the multifaceted roles of mitochondria in UM, including mitochondrial DNA copy-number alterations, reprogramming of mitochondria-related metabolic genes, and mitochondria-dependent autophagy. Moreover, mitochondria modulate UM progression partly through the PI3K/AKT axis. Natural compounds and small-molecule drugs that impair mitochondrial function have also shown promising activity in inducing UM cell dysfunction. These findings provide new insights into UM pathogenesis and highlight mitochondria as potential therapeutic targets.
