Construction and Evaluation of "Constitution-disease-syndrome" Trinity Model for Rodents with Qi Deficiency
10.13422/j.cnki.syfjx.20250312
- VernacularTitle:“体-病-证”三位一体气虚啮齿类动物模型的构建与评价
- Author:
Yasheng DENG
1
;
Jiang LIN
2
;
Yujiang XI
3
;
Qian ZHOU
1
;
Yanping FAN
4
;
Wenyue LI
4
;
Yonghui LIU
4
;
Zhaobing NI
4
;
Qiu CHEN
1
;
Xi MING
3
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine，Nanning 610075，China
2. Guangxi University of Chinese Medicine，Nanning 530200，China
3. The First Clinical Medical College，Yunnan University of Chinese Medicine，Kunming 650051，China
4. Fangchenggang Hospital of Traditional Chinese Medicine， Fangchenggang 538000，China
- Publication Type:Journal Article
- Keywords:
"constitution-disease-syndrome" trinity;
Qi deficiency constitution;
Qi deficiency syndrome;
Qi deficiency disease-syndrome combination;
rodent models
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(8):274-284
- CountryChina
- Language:Chinese
-
Abstract:
The theory of constitution in traditional Chinese medicine （TCM） has emerged as a new discipline in recent years. Constitution plays a vital role in the onset，progression，transformation，and prognosis of diseases. At present，some clinical scholars have adopted a novel diagnostic and treatment model of "constitution differentiation-disease identification-syndrome differentiation"，in which constitution is regarded as a core element throughout the diagnostic and therapeutic process. Constitution is closely associated with etiology，onset，pathogenesis，syndrome differentiation，and treatment. Against this background，the construction of animal models based on constitution holds far-reaching significance for advancing clinical research. This paper focuses on the construction and evaluation of rodent models with Qi-deficiency constitution，aiming to explore how to further induce Qi-deficiency syndromes and related disease states on the basis of Qi-deficiency constitution models，thereby developing an integrated animal model that embodies the trinity of "constitution-disease-syndrome". The establishment of this model not only provides a solid experimental foundation for the development of new therapies and drugs in TCM targeting specific constitutions，diseases，and syndromes，but also greatly promotes the modernization and scientific advancement of TCM theory. By comprehensively applying multidisciplinary technologies and methods，the study evaluates the model's validity，reliability，and practicality，with the aim of opening new avenues for future research in TCM and promoting the development of the field.
