Research advances on a antibacterial-remineralization-infiltration synergistic strategy to treat dental hard tissue diseases
10.12016/j.issn.2096-1456.202550483
- Author:
ZHANG Xu
1
;
YANG Qingyi
1
Author Information
1. Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University School and Hospital of Stomatology
- Publication Type:Journal Article
- Keywords:
antibacterial;
remineralization;
infiltration;
metal ions;
antibacterial peptides;
nanomaterials;
bioactive glass;
amorphous calcium phosphate;
dental caries;
interrupt dental caries;
dentine hypersensitivity;
wedge-shaped defect;
dental erosion
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2026;34(3):213-225
- CountryChina
- Language:Chinese
-
Abstract:
This paper reviews research progress on a antibacterial-remineralization-infiltration synergistic strategy for the prevention and treatment of dental hard tissue diseases. Dental caries is a chronic infectious disease caused by cariogenic bacteria. Traditional fluoride prevention methods are unable to effectively halt the progression of deep caries due to limited antibacterial capacity and poor deep penetration. To address this, researchers have proposed an interruption of dental caries strategy that integrates antibacterial, remineralization, and infiltration functions. This approach utilizes antibacterial components, such as metal ions, antibacterial peptides, and nanoparticles, to suppress cariogenic bacterial activity. Bioactive glass and amorphous calcium phosphate materials induce in situ hydroxyapatite deposition to achieve dental hard tissue remineralization. Simultaneously, the materials penetrate deep into the micro-pores of a lesion via high permeability, forming a physical barrier that blocks acid erosion and plaque re-invasion. This strategy is applicable not only for minimally invasive intervention in early caries but also extends to treating non-carious conditions, such as dentine hypersensitivity, wedge-shaped defect, and tooth erosion. Multiple in vitro and animal studies demonstrate that multifunctional coatings and nanocomposite systems developed under this systemic approach significantly enhance treatment efficacy for dental hard tissue diseases. Future advancements in biomimetic materials and smart delivery systems hold promise for achieving higher levels of structure-function reconstruction, which will propel dental hard tissue disease treatment toward precision, minimally invasive, and intelligent approaches.
- Full text:2026032015044541060抗菌-再矿化-渗透协同策略治疗牙体硬组织疾病的研究进展.pdf
