Association of oxidative stress-related genes with lung cancer: A genome-wide Mendelian randomization study
- VernacularTitle:氧化应激相关基因与肺癌的因果关系：一项全基因组孟德尔随机化研究
- Author:
Siding ZHOU
1
;
Hongbi XIAO
1
;
Mingjun GAO
2
;
Mengmeng WANG
2
;
Xiaolin WANG
3
;
Yusheng SHU
3
Author Information
1. Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu, P. R. China
2. Dalian Medical University, Dalian, 116000, Liaoning, P. R. China
3. Department of Thoracic Surgery, Northern Jiangsu People s Hospital, Clinical Medical School, Yangzhou University, Yangzhou, 225000, Jiangsu, P. R. China
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
oxidative stress;
lung cancer risk;
colocalization;
quantitative trait locus
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(11):1567-1571
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify causal effects and potential mechanisms of oxidative stress (OS)-related genes in lung cancer. Methods OS-related genes were extracted from the GeneCards database. Integration analysis of genome-wide association study (GWAS) data for lung cancer with gene expression and DNA methylation quantitative trait locus (QTL), including eQTL and mQTL in blood was performed using the summary data-based Mendelian randomization (SMR) approach to determine the causal relationship between OS-related genes and lung cancer risk. Colocalization analysis of OS-related gene QTL and lung cancer risk locus was performed to gain insight into the potential regulatory mechanisms of lung cancer risk. Results A total of 1 188 OS-related genes were obtained from the GeneCards database. A potential causal relationship between OS-related genes and lung cancer was identified by SMR analysis. AGER expression level [OR=1.944, 95%CI (1.431, 2.640), P<0.001], and ATF6B expression level [OR=1.508, 95%CI (1.287, 1.767), P<0.001] were associated with lung cancer risk. Meanwhile, ATF6B methylation level was also associated with lung cancer risk. Conclusion OS-related genes are associated with lung cancer, which may be a potential target of anti-cancer drugs.
