Impact mechanisms, assessment methods, and prevention and management of right heart failure associated with left ventricular assist devices
- VernacularTitle:左心室辅助装置植入患者右心功能不全的影响机制、评估方法及预防管理
- Author:
Kunsheng LI
1
,
2
,
3
;
Yumeng WANG
1
;
Lin MI
1
;
Wenjie JI
1
;
Yongqing CHENG
1
;
Zhenjun XU
1
;
Dongjin WANG
1
;
Jun PAN
1
Author Information
1. Department of Cardiac Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, P. R. China
2. Gulou Clinical College of Nanjing Medical University, Nanjing, 210008, P. R. China
3. Gulou Clinical College, Nanjing University of Chinese Medicine, Nanjing, 210008, P. R. China
- Publication Type:Journal Article
- Keywords:
Left ventricular assist;
heart failure;
mechanism of action;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(11):1655-1663
- CountryChina
- Language:Chinese
-
Abstract:
Left ventricular assist device (LVAD) serves as a critical therapeutic option for patients with end-stage heart failure, significantly enhancing survival rates and quality of life. However, LVAD implantation exerts complex and profound effects on right ventricular (RV) function, with RV dysfunction emerging as a key factor influencing the prognosis of LVAD patients. This article systematically reviews the relationship between LVAD and RV function, exploring the importance of RV function in LVAD patients, assessment methods, underlying mechanisms of impact, and strategies for prevention and management. Comprehensive evidence suggests that preoperative evaluation of RV function is crucial for predicting the risk of RV dysfunction, while effective prevention and management rely on preoperative optimization, meticulous intraoperative techniques, rigorous postoperative monitoring, and multidisciplinary collaboration. Furthermore, this review discusses the potential and future directions of emerging technologies, such as improved LVAD designs, biventricular assist devices, gene therapy, and personalized medicine, in ameliorating RV dysfunction. In conclusion, RV function is one of the key determinants of successful LVAD therapy. Through comprehensive assessment, prevention, and management of RV function, coupled with the application of novel technologies, the clinical outcomes of LVAD patients can be further improved.
