Association of Controlling Nutritional Status score with prognosis and clinicopathological characteristics of patients with non-small cell lung cancer: A systematic review and meta-analysis
- VernacularTitle:CONUT评分与非小细胞肺癌患者预后和临床病理特征相关性的系统评价与Meta分析
- Author:
Xianliang TANG
1
;
Xiaofeng HE
2
;
Wenping ZHANG
1
Author Information
1. Department of Thoracic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, 046000, Shanxi, P. R. China
2. Institute of Evidence-based Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, 046000, Shanxi, P. R. China
- Publication Type:Journal Article
- Keywords:
Controlling Nutritional Status score;
non-small cell lung cancer;
prognosis;
clinicopathologic feature;
systematic review/meta-analysis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(11):1642-1648
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the prognostic significance of the Controlling Nutritional Status (CONUT) score in patients with non-small cell lung cancer (NSCLC) and its association with clinicopathological characteristics. Methods The relevant studies investigating the association between CONUT score and prognosis of NSCLC patients were systematically searched in the PubMed, Web of Science, EMbase, Cochrane Library, CNKI, Wanfang Database and other databases from their inception to July 2023. Two independent researchers screened the references according to predefined inclusion and exclusion criteria, extracted data and conducted quality assessment. The quality of included references was evaluated using New Castle-Ottawa Scale (NOS). The meta-analysis was performed using Stata 17.0 software, and a combined hazard ratio (HR) or odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association of CONUT score with prognosis and clinicopathological characteristics in NSCLC patients. Results A total of 17 cohort studies, comprising 5182 NSCLC patients with stage Ⅰ-Ⅳ, were included in this analysis. All studies had a NOS≥6 points. The meta-analysis showed that there was a significant correlation between CONUT score and overall survival (OS) as well as disease-free survival (DFS) among NSCLC patients: the higher the score, the shorter the OS [HR=1.87, 95%CI (1.58, 2.21), P<0.001] and DFS [HR=1.91, 95%CI (1.63, 2.24), P<0.001]. These differences were statistically significant. Furthermore, CONUT score was significantly associated with age, smoking status, tumor stage, and N stage (P<0.05). Conclusion A higher CONUT score is associated with a poorer OS and DFS in patients with NSCLC, and CONUT score can be used as a potential predictor of NSCLC prognosis.
