Safety and efficacy of simultaneous surgery and thermal ablation in sequential treatment of multiple primary lung cancer: A retrospective cohort study
- VernacularTitle:同期手术联合热消融序贯治疗多原发肺癌安全性与有效性的回顾性队列研究
- Author:
Congjia XIAO
1
,
2
;
Yuchen HUANG
1
;
Zhenghao DONG
1
;
Jingwen ZHANG
3
;
Cheng SHEN
1
;
Jian ZHOU
1
;
Hu LIAO
1
;
Lunxu LIU
1
Author Information
1. Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
2. Department of Thoracic Surgery, Shangjin Hospital of West China Hospital, Sichuan University/Chengdu Shangjin Nanfu Hospital, Chengdu, 610041, P. R. China
3. West China School of Medicine, Sichuan University, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Multiple primary lung cancer;
surgery;
ablation;
safety;
efficacy
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2025;32(10):1411-1418
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of simultaneous surgical resection combined with thermal ablation in sequential treatment of patients with multiple primary lung cancer (MPLC). Methods Patients with MPLC who underwent simultaneous, sequential surgical resection combined with thermal ablation at Shangjin Branch of West China Hospital of Sichuan University from April 2023 to May 2024 were retrospectively included, and their perioperative and follow-up data were analyzed. Results A total of 23 patients with MPLC were enrolled, including 4 males and 19 females, with a mean age of (51.61±12.38) years. Cumulatively, 48 lesions were resected and 23 lesions were ablated. About half of the patients (52.17%) had surgery and ablation treatment located in the same lung. All patients completed the combined treatment without intraoperative complications. Four patients had postoperative complications, and were effectively managed and successfully discharged. The median postoperative hospital stay was 4.00 (4.00, 4.00) days. The average follow-up duration was (11.78±4.90) months, with a local control rate of 100.00% at 6 months postoperatively. No deaths or tumor occurred during the follow-up. Conclusion Simultaneous surgery with thermal ablation in sequential treatment for MPLC is safe, flexible and effective, providing a new option for this group of patients, but further studies are needed to evaluate its long-term efficacy.
