Hair growth-promoting effects of Stellera chamaejasme L. extract on C57BL/6 mice via induction of anagen phase genes

Jin-Woo Kim; Banzragch Dorjsembe; Chu Who Nho; Pahn-Shick Chang; Jin-Chui Kim

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Hair growth-promoting effects of Stellera chamaejasme L. extract on C57BL/6 mice via induction of anagen phase genes

Author: Jin-Woo Kim ¹ ; Banzragch Dorjsembe ² ; Chu Who Nho ³ ; Pahn-Shick Chang ⁴ ; Jin-Chui Kim ⁵
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1. Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul 08826, Republic of Korea Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea
2. Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea Division of Bio-Medical Science and Technology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea
3. Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea
4. Interdisciplinary Program in Agricultural Genomics, Seoul National University, Seoul 08826, Republic of Korea Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea Center for Food and Bioconvergence, Seoul National University, Seoul 08826, Republic of Korea Center for Agricultural Microorganism and Enzyme, Seoul National University, Seoul 08826, Republic of Korea
5. Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea Division of Bio-Medical Science and Technology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea
Publication Type:Journal Article
Keywords: Stellera chamaejasme L.; Traditional medicinal herb; Hair growth; Anagen phase
From: Journal of Traditional Chinese Medical Sciences 2025;2025(3):415-421
CountryChina
Language:English
Abstract: ObjectiveTo evaluate the effects of Stellera chamaejasme L. (S. chamaejasme, Rui Xiang Lang Du) extract on hair growth in a mouse model.MethodsThe extract was prepared using 95% ethanol and topically applied as a 1% or 3% solution to the dorsal skin of shaved mice for 16 consecutive days. A control mouse group received an equal volume of vehicle for the same period. After 16 days, the dorsal skin was histologically examined through hematoxylin-eosin staining. Further, quantitative real time-polymerase chain reaction was performed on skin tissue lysates to evaluate the expression levels of mRNAs encoding proteins involved in hair growth, including WNT10A, noggin (NOG), transforming growth factor-β receptor 1 (TBR1), epidermal growth factor (EGF), versican, fibroblast growth factor 10 (FGF10), lymphoid enhancer-binding factor 1 (LEF1), and transforming growth factor-β (TGF-β).ResultsCompared with vehicle, S. chamaejasme extract dose-dependently enhanced hair growth. Histological analysis revealed that S. chamaejasme extract increased the number and diameter of hair follicles in subcutaneous tissue, as well as dermal layer thickness, which are indicative of anagen phase induction. Additionally, S. chamaejasme extract upregulated the mRNA expression levels of WNT10A, NOG, TBR1, EFG, FGF10, LEF1, and TGF-β.ConclusionThe results suggest that S. chamaejasme extract could be a potential treatment for promoting hair growth.