Research Progress on Tumor Microenvironment in Lung Cancer Spine Metastasis
10.3971/j.issn.1000-8578.2026.25.0679
- VernacularTitle:肿瘤微环境在肺癌脊柱转移中的研究进展
- Author:
Hongyang FU
1
;
Yizhi LIU
1
;
Yitong SHE
1
;
Yaxin DU
1
;
Ruixia WU
1
;
Manglai LI
1
;
Yong ZHU
2
Author Information
1. Graduate School of Inner Mongolia Medical University, Hohhot 010059, China.
2. Department of Bone and Soft Tissue Oncology, Peking University Cancer Hospital, Inner Mongolia Hospital, Hohhot 010010, China.
- Publication Type:REVIEWS
- Keywords:
Lung cancer;
Spinal metastases;
Tumor microenvironment;
Emerging therapeutic strategies
- From:
Cancer Research on Prevention and Treatment
2026;53(2):158-164
- CountryChina
- Language:Chinese
-
Abstract:
The spine is the most common site of skeletal metastasis in lung cancer, which frequently leads to severe complications such as pathological fracture and neurological compromise and is associated with poor prognosis. The development and progression of spinal metastasis from lung cancer are linked to the unique local microenvironment and tumor microenvironment (TME) of the vertebral column. During metastatic evolution, the dense vascular network of the spine and a plethora of signaling molecules, together with the complex cellular constituents and their intricate interactions within the TME, all cooperate to facilitate the tumor invasion and colonization of the vertebral compartment. Mechanistic studies delineating the role of the TME in spinal metastasis from lung cancer have markedly expanded, fostering the emergence of innovative therapeutic strategies—including nanomedicines, sono-photodynamic therapy, gene therapy, and combination regimens. These strategies demonstrate remarkably potential for clinical translation and offer new directions for the precision management of spinal metastasis from lung cancer.
