PCDHGB7 Methylation Characteristics and Their Clinical Significance in Lung Adenocarcinoma Based on the TCGA Database
10.3971/j.issn.1000-8578.2026.25.0724
- VernacularTitle:基于TCGA数据库探索肺腺癌组织中PCDHGB7的甲基化特征及其临床意义
- Author:
Runhua YU
1
;
Zhitao GU
2
;
Wentao FANG
3
;
Feng YAO
2
Author Information
1. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China;Shanghai Key Laboratory of Thoracic Tumor Biotherapy, Shanghai 200030, China.
2. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
3. Department of Thoracic Surgery, Shanghai East Hospital, Tongji University, Shanghai 200120, China.
- Publication Type:CLINICALRESEARCH
- Keywords:
Lung adenocarcinoma;
DNA methylation;
Prognosis;
TCGA database
- From:
Cancer Research on Prevention and Treatment
2026;53(2):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study used The Cancer Genome Atlas (TCGA) database to investigate the methylation levels of PCDHGB7 in lung adenocarcinoma tissues and analyze its association with clinical pathological features of lung adenocarcinoma, and its prognostic predictive value. Methods Methylation data of PCDHGB7 from 473 lung adenocarcinoma tissues and 32 normal tissues in the TCGA database were derived and analyzed to assess between-group variance and determine the correlation of methylation levels with clinical pathological features and overall survival. Results PCDHGB7 exhibited significantly higher methylation levels in lung adenocarcinoma tissues than in normal tissues (P<0.001), demonstrating a strong discriminative ability for lung adenocarcinoma (AUC=0.926, P<0.001). The methylation level was strongly associated with gender (P=0.047) and T stage (P=0.013). The critical prognostic sites of PCDHGB7 were identified through univariate Cox regression analysis. We found significant differences in overall survival between patient groups with low or high methylation levels (P=0.0099). Conclusion PCDHGB7 shows significantly elevated methylation in lung adenocarcinoma, which correlates with tumor malignancy and possesses certain prognostic predictive potential.
