Impact of Nutritional Support on Antitumor Efficacy in the Era of Immunotherapy
10.3971/j.issn.1000-8578.2026.25.0633
- VernacularTitle:免疫治疗时代营养支持的意义
- Author:
Xiaojun QIAN
1
;
Ling LU
2
;
Xuecheng HU
2
;
Shiwei LI
1
;
Wenjun GAO
1
;
Li PAN
1
;
Yubei SUN
1
;
Suyi LI
1
Author Information
1. Department of Oncological Nutrition and Metabolism, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China.
2. Graduate School, Anhui Medical University, Hefei 230001, China.
- Publication Type:SPECIALFEATURE
- Keywords:
Cancer;
Malnutrition;
Metabolism;
Immunotherapy;
Immunonutrition
- From:
Cancer Research on Prevention and Treatment
2026;53(2):89-95
- CountryChina
- Language:Chinese
-
Abstract:
Despite breakthroughs in immunotherapy for solid tumors, significant variations in treatment efficacy persist. Up to 80% of cancer patients suffer from malnutrition, which leads to: lymphoid atrophy and reduced T-cell reserves; deficiency of substrates required for T-cell activation and expansion; concurrent inflammation hindering T-cell infiltration into tumors; and cachexia accelerating PD-1 antibody clearance. Clinical studies confirm that severe malnutrition significantly impairs immune responses and increases the risk of treatment toxicity. Therefore, implementing standardized nutritional therapy is crucial for optimizing the reserve, activation, expansion, and infiltration capacity of immune cells, thereby providing a sound immune system foundation for immunotherapy. Immunonutrition therapy, by enhancing immunonutrients such as arginine, omega-3 polyunsaturated fatty acids, and nucleotides, reduces the secretion of pro-inflammatory mediators and promotes T-cell activation and proliferation. This enhances anti-tumor immune responses, prolongs survival, and advances cancer treatment towards multimodal combination and precision approaches.
