Mechanisms of Tripterygium wilfordii and Its Active Ingredients in Treatment of Diabetic Kidney Disease： A Review
10.13422/j.cnki.syfjx.20251244
- VernacularTitle:雷公藤及其活性成分治疗糖尿病肾病的作用机制研究进展
- Author:
Peidong ZHAO
1
;
Yanyan GUO
2
;
Xiangge REN
1
;
Jiawei ZHANG
1
;
Wensheng ZHAI
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine， Henan Children's Hospital， Zhengzhou 450000， China
2. The Fourth Clinical Medical College of Xinjiang Medical University， Urumqi 830000， China
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
active ingredients;
diabetic kidney disease;
mechanisms;
research advances
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(7):352-362
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD）， a common complication of diabetes mellitus， is a leading global cause of end-stage renal disease （ESRD）. Current therapeutic strategies primarily focus on symptomatic management but exhibit limited efficacy in halting disease progression to ESRD， and some drugs carry non-negligible toxic side effects. Traditional Chinese medicine （TCM） has a long history in treating DKD， with single TCM and TCM compounds demonstrating unique advantages in multi-target， multi-pathway， and multi-effect therapeutic interventions. Tripterygium wilfordii （TW）， known for its effects in promoting blood circulation， dredging collaterals， dispelling wind， removing dampness， reducing swelling， and alleviating pain， contains bioactive components such as Tripterygium glycosides （TWG）， triptolide （TPL）， tripdiolide （TPD）， and celastrol （CEL）. The active ingredients possess various functions， including regulating immune-inflammatory balance， ameliorating renal fibrosis and glomerulosclerosis， combating oxidative stress， protecting podocytes， and improving glucose and lipid metabolism， all of which play a significant role in the treatment of DKD. This review summarized the mechanisms underlying the therapeutic effects of T. wilfordii and its active ingredients on DKD， aiming to provide insights for clinical management and novel drug development of DKD.
