Mechanisms of Traditional Chinese Medicine in Treatment of Ulcerative Colitis Based on AMPK Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250738
- VernacularTitle:基于AMPK信号通路探讨中医药治疗溃疡性结肠炎的机制研究进展
- Author:
Keqiu YAN
1
;
Xiaoyu ZHANG
2
;
Yifan CAI
1
;
Wenjie XIAO
2
;
Xinkun BAO
2
;
Guangjun SUN
2
;
Aizhen LIN
1
Author Information
1. College of Traditional Chinese Medicine（TCM）， Hubei University of Chinese Medicine， Wuhan 430065， China
2. Hubei Provincial Hospital of TCM， Affiliated Hospital of Hubei University of Chinese Medicine， Wuhan 430061， China
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
adenosine monophosphate-activated protein kinase （AMPK） signaling pathway;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(7):341-351
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC）， a chronic relapsing inflammatory bowel disease， involves multifaceted pathological mechanisms such as intestinal barrier dysfunction， immune dysregulation， and oxidative stress. Current therapeutic strategies remain limited in efficacy and safety. In recent years， the adenosine monophosphate-activated protein kinase （AMPK） signaling pathway has emerged as a pivotal therapeutic target for UC due to its central role in energy metabolism， inflammatory regulation， and intestinal homeostasis. This article systematically reviewed the mechanisms by which traditional Chinese medicine （TCM） prevented and treated UC through the regulation of the AMPK signaling pathway， with a focus on elucidating AMPK's multidimensional regulatory network in inflammatory signaling crosstalk， alleviating oxidative stress， restoring intestinal immune balance， repairing the intestinal barrier， and modulating gut microbiota. Leveraging its unique advantages of multi-target engagement and low toxicity， TCM demonstrates promising potential in UC treatment and has become a focal area of research. By systematically summarizing and synthesizing the existing literature on TCM-mediated AMPK pathway modulation in UC， this review aims to provide a theoretical foundation for advancing mechanistic research and clinical interventions in UC.
