Intervention of Signaling Pathways Related to Ulcerative Colitis with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20251695
- VernacularTitle:中医药干预溃疡性结肠炎相关信号通路的研究进展
- Author:
Hao WANG
1
;
Jiali DING
2
;
Guangjun SUN
3
;
Xiaoyu ZHANG
3
;
Aizhen LIN
3
Author Information
1. College of Traditional Chinese Medicine（TCM）， Hubei University of Chinese Medicine，Wuhan 430065，China
2. Jingmen People's Hospital，Jingmen 448000，China
3. Hubei Provincial Hospital of TCM，Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430074，China
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
signaling pathway;
traditional Chinese medicine;
anti-inflammation;
immunomodulation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(7):331-340
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a common digestive disease characterized by recurrence and remission alternation，which seriously affects the life quality and physical and mental health of patients. The pathogenesis of UC is complex，and studies have shown that the occurrence and development of UC are closely related to the transduction of multiple signaling pathways. The current western medicine treatment has many problems，such as single action target，more adverse reactions，poor patient tolerance，and easy recurrence after stopping the medicine. Traditional Chinese medicine has the advantages such as multi-targets，multi-pathways， and fewer adverse reactions， elucidating that the action mechanism of traditional Chinese medicine in the treatment of UC is the focus of current research. Therefore， this paper conducted a systematic review on how traditional Chinese medicine exerts therapeutic effects by regulating the signaling pathways related to UC in recent years，and it was found that traditional Chinese medicine can regulate nuclear factor-κB （NF-κB），adenylate-activated protein kinase （AMPK）/mammalian target of rapamycin （mTOR），Janus tyrosine protein kinase （JAK）/signal transducer and activator of transcription （STAT），phosphatidylinositol 3-kinase （PI3K） /protein kinase B （Akt），NOD-like receptor thermoprotein structural domain-related protein 3 （NLRP3）/cysteine protease-1 （Caspase-1），nuclear respiratory factor 2 （Nrf2）/heme oxygenase-1 （HO-1）， and several other pathways，thereby inhibiting oxidative stress and cellular pyroptosis，regulating the Tregs/Th17 cellular balance， promoting autophagic response and M2-type macrophage polarization，restoring the diversity and abundance of intestinal flora，promoting the repair of intestinal mucosal barrier function，and alleviating the inflammatory damage of UC colonic tissues. The holistic concept and evidence-based treatment of traditional Chinese medicine were combined with the modern molecular mechanism research of traditional Chinese medicine， and the traditional Chinese medicine combinations with different mechanisms， following regulation， were formulated into compound formulas or pairs of medicines according to the pattern of evidence. It is expected to achieve better therapeutic efficacy and to provide ideas and references for the modification of classic compound formulae of traditional Chinese medicine in UC treatment and clinical translation.
