Intervention of Bronchial Asthma by Regulating JAK/STAT Signaling Pathway with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20251491
- VernacularTitle:中医药调控JAK/STAT信号通路干预支气管哮喘研究进展
- Author:
Ruiyi CHEN
1
;
Weike LI
1
;
Ju YANG
1
;
Zhiwan WANG
1
Author Information
1. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
Janus kinases （JAK）/signal transducers and activators of transcription （STAT） signaling pathway;
asthma;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(7):321-330
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （abbreviated as asthma） is one of the common inflammatory diseases in the chronic airway of the respiratory system. Recurrent wheezing，shortness of breath，chest tightness， and cough are the main symptoms，which are easy to repeat，protracted and difficult to cure，and seriously affect the patients' life quality. The Janus kinases （JAK）/signal transducers and activators of transcription （STAT） signaling pathway is involved in the regulation of cellular inflammatory response，oxidative stress，apoptosis， and other biological processes. It plays a key role in the occurrence and development of asthma. Traditional Chinese medicine intervenes in asthma based on the JAK/STAT signaling pathway in multiple stages and targets. The specific mechanism is related to inhibiting airway inflammation and anti-oxidative stress，alleviating airway remodeling，affecting airway mucus hypersecretion，inhibiting high airway response， and regulating immune response，which demonstrates the characteristics and advantages of traditional Chinese medicine in treating asthma. Based on this，by referring to relevant literature，this paper systematically sorted out the JAK/STAT signaling pathway and its action mechanism in the occurrence and development of asthma. It also systematically summarized the efficacy and specific mechanism of monomers， compounds， and compound formulas of traditional Chinese medicine， as well as the external treatment methods by regulating the JAK/STAT signaling pathway to intervene in asthma. It aims to effectively prevent and control the occurrence and development of asthma in clinic， providing a reference for the methods of prevention and treatment of asthma with traditional Chinese medicine.
