Diabetic Kidney Disease and Gut-kidney Axis： A Review
10.13422/j.cnki.syfjx.20251125
- VernacularTitle:糖尿病肾脏疾病与“肠-肾轴”研究进展
- Author:
Yingchao WANG
1
;
Yexin CHEN
2
;
Hua ZHANG
2
;
Jiangteng LIU
2
;
Zhichao RUAN
2
;
Xingru PAN
2
;
Weijun HUANG
2
;
Jinxi ZHAO
2
Author Information
1. Beijing Aerospace General Hospital，Beijing 100076，China
2. Dongzhimen Hospital， Beijing University of Chinese Medicine，Beijing 100070，China
- Publication Type:Journal Article
- Keywords:
diabetic kidney disease;
gut microbiota;
gut-kidney axis;
traditional Chinese medicine intervention;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(7):310-320
- CountryChina
- Language:Chinese
-
Abstract:
With the rising incidence of diabetes， diabetic kidney disease （DKD） has become a significant global health burden. Although current prevention and treatment strategies can partially delay the progression of DKD， the risk of patients advancing to end-stage renal disease remains high. Since the concept of the "gut-kidney axis" was first introduced at the International Congress on Dialysis in 2011， research on the role of gut microbiota in the pathogenesis of DKD has received increasing attention. This review summarizes the current research on gut microbiota， explores the mechanisms through which it contributes to DKD development， and outlines clinical approaches for DKD prevention and treatment based on the "gut-kidney axis" theory. Evidence indicates that dietary interventions， intake of probiotics or prebiotics， use of metformin and novel antidiabetic drugs， and application of traditional Chinese medicine （TCM） compound formulas can effectively improve gut microbiota composition， influence metabolite production， and restore the intestinal mucosal barrier. These interventions can further regulate intestinal innate immunity and inflammatory responses， thereby modulating the progression of DKD. Despite challenges posed by the traditional oral administration of water-decocted TCM compound formulas and the complexity of their ingredients， increasing evidence suggests that TCM may indirectly affect the occurrence and development of DKD by modulating gut microbiota. This finding provides a new perspective on the potential mechanisms of TCM in DKD treatment and may offer novel strategies for DKD prevention and therapy.
