Identification and transfusion strategy for anti-Fy
combined with Rh Blood Group system antibodies
10.13303/j.cjbt.issn.1004-549x.2026.02.011
- VernacularTitle:抗-Fy
合并Rh血型系统抗体的鉴定及输血策略
- Author:
Wenju XIE
1
;
Chengxin ZHANG
1
;
Qiushi WANG
1
;
Yang LI
1
Author Information
1. Department of Blood Transfusion, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China
- Publication Type:Journal Article
- Keywords:
Duffy blood group system;
anti-Fya antibody;
Rh blood group system;
targeted recruitment
- From:
Chinese Journal of Blood Transfusion
2026;39(2):236-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the identification process of a case with anti-Fy
combined with Rh blood group system antibodies and to review the transfusion strategy and epidemiological characteristics of Duffy blood group system antibodies. Methods: The antibody specificity of a patient diagnosed with liver cirrhosis, who exhibited unexpected antibodies, was determined using the microcolumn gel method, enzyme method, and elution test. A retrospective analysis was performed to assess the incidence and clinical characteristics of antibodies associated with the Duffy blood group system among a cohort of 652 003 patients treated at our hospital from 2014 to 2024. Results: The patient's serum contained anti-Fy
, anti-c, and anti-E antibodies. Through the targeted recruitment of African international students, the patient successfully received four units of Fy
-negative blood that matched the ABO and Rh phenotypes. Between 2014 and 2024, the incidence of Duffy blood group system antibodies was 0.005 7% (37 out of 652 003), with 9 cases (24.3%) combined with Rh antibodies. Conclusion: Patients with anti-Fy
combined with Rh antibodies require Fy
-negative blood with matched Rh phenotypes. Targeted recruitment based on racial antigen differences can effectively resolve rare blood type transfusion challenges.
