Current application status of stem cell therapy in the field of lung transplantation
10.12464/j.issn.1674-7445.2025233
- VernacularTitle:干细胞治疗在肺移植领域中的应用现状
- Author:
Mingyu GU
1
;
Xiangyun ZHENG
1
;
Ji’er MA
1
;
Xiaohan JIN
1
;
Zhiqiang DENG
1
;
Haoji YAN
1
;
Dong TIAN
1
Author Information
1. Department of Thoracic Surgery, Institute of Thoracic Tumor, Lung Transplantation Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China.
- Publication Type:ReviewArticle
- Keywords:
Stem cell therapy;
Lung transplantation;
Immune regulation;
Tissue repair;
End-stage lung disease;
Embryonic stem cell;
Umbilical cord mesenchymal stem cell;
Lung tissue regeneration
- From:
Organ Transplantation
2026;17(2):311-318
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, research on stem cell therapy in the field of lung transplantation has gradually increased, demonstrating its potential in improving the outcomes of lung transplantation. As a treatment option for end-stage lung diseases, lung transplantation faces challenges such as scarcity of donor organs, postoperative complications and rejection. Stem cells, with their self-renewal and multi-directional differentiation capabilities, have emerged as strong candidates for alternative or adjunctive treatments. Current studies show that embryonic stem cells and umbilical cord mesenchymal stem cells play significant roles in lung tissue regeneration and immune regulation. However, stem cell therapy still needs to overcome issues such as the selection of cell sources, low survival rates after transplantation and unclear long-term efficacy in clinical applications. Future research should focus on exploring new stem cell sources, improving transplantation techniques and establishing efficacy evaluation systems.
