Relationship between ischemia-reperfusion injury and rejection
10.12464/j.issn.1674-7445.2025263
- VernacularTitle:缺血-再灌注损伤和排斥反应的关系
- Author:
Aizheng XI
1
;
Han XU
1
;
Jun LUO
1
;
Zhongzhong LIU
1
Author Information
1. Zhongnan Hospital of Wuhan University , Institute of Liver and Biliary Diseases of Wuhan University, Transplant Medicine Center of Wuhan University, Transplant Medicine Technology Key Laboratory of Hubei Province, Wuhan 430071, China.
- Publication Type:ReviewArticle
- Keywords:
Ischemia-reperfusion injury;
Rejection;
Organ transplantation;
Immune response;
Damage-associated molecular pattern;
Inflammatory cascade reaction;
T cell-mediated rejection;
Antibody-mediated rejection
- From:
Organ Transplantation
2026;17(2):304-310
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury of solid organs is a common complication during transplantation, but its mechanism remains unclear and there are no effective prevention and treatment methods. Rejection is a common immune response of the graft, which is classified into hyperacute rejection, acute rejection and chronic rejection. Rejection and ischemia-reperfusion injury of solid organs may share some common mechanisms, and further research on their correlation may provide strategies for the prevention and treatment of ischemia-reperfusion injury of solid organs. This article mainly reviews the association between rejection and ischemia-reperfusion injury of solid organs.
