Progress in non-invasive detection of acute rejection after liver transplantation
10.12464/j.issn.1674-7445.2025258
- VernacularTitle:肝移植术后急性排斥反应的无创检测手段进展
- Author:
Yanhe LIU
1
;
Xiru TANG
1
;
Mingxiang CHENG
1
Author Information
1. Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
- Publication Type:ReviewArticle
- Keywords:
Liver transplantation;
Acute rejection;
Non-invasive detection;
Imaging;
Biomarker;
Cytokine;
Immune cell;
Transcription factor
- From:
Organ Transplantation
2026;17(2):296-303
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is a key treatment for end-stage liver disease and primary liver cancer, yet acute rejection remains a major factor affecting the prognosis of recipients. At present, the diagnosis of acute rejection mainly relies on liver biopsy, but it is traumatic and has diagnostic errors. Non-invasive detection methods such as ultrasound elastography and cytokine assays can assist in the diagnosis of acute rejection, but a single method cannot completely replace liver biopsy. Combining multiple non-invasive methods to predict and diagnose rejection after liver transplantation is likely the direction of future research. Therefore, this article reviews non-invasive approaches for acute rejection after liver transplantation, including imaging evaluation and various biomarkers, in order to achieve personalized immunosuppressive management and improve the prognosis of liver transplant recipients.
