Preventive effect of LifePort combined with polymyxin B on donor-derived infections in kidney transplantation
10.12464/j.issn.1674-7445.2025283
- VernacularTitle:LifePort联合多黏菌素B对肾移植供者来源性感染的预防作用
- Author:
Xiaomin LI
1
;
Yuewei YIN
1
;
Chenming ZHAO
1
;
Yalin NIU
1
;
Kailong LIU
1
;
Pingying GUO
1
;
Wei LI
1
;
Baosai LU
1
Author Information
1. Department of Urology, the Second Hospital of Hebei Medical University, Shijiazhuang 050017, China.
- Publication Type:OriginalArticle
- Keywords:
Kidney Transplantation;
Hypothermic machine perfusion;
Polymyxin B;
Decontamination;
Multidrug-resistant bacteria;
LifePort;
Preservation solution;
Donor-derived infection
- From:
Organ Transplantation
2026;17(2):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of LifePort combined with polymyxin B in preventing donor-derived infections caused by preservation solution contamination. Methods Clinical data of 110 kidney transplant recipients were retrospectively analyzed. According to the decontamination status of preservation solution, the recipients were divided into the decontamination group (n=62) and the non-decontamination group (n=48). The general data of the two groups were compared, and the preventive effect of polymyxin B on possible donor-derived infections (p-DDI) was analyzed, especially infections associated with multidrug-resistant Gram-negative bacteria (MDR GNB). Results There were no statistically significant differences in baseline data (gender, age, preservation solution contamination status, etc.) between the decontamination group and the non-decontamination group (all P > 0.05). The overall contamination rate of preservation solution was 80.0%, and 68 contaminated samples were with single microorganism and 20 with multiple microorganisms. Coagulase-negative staphylococci, Enterococcus and Klebsiella pneumoniae were the most common microorganisms in the positive samples. Fifteen cases of preservation solution were contaminated by MDR GNB, including 10 cases in the non-decontamination group and 5 cases in the decontamination group, with no statistically significant difference between the two groups (P = 0.053). Postoperative infection-related events occurred in 69 recipients, including 39 cases in the non-decontamination group and 30 cases in the decontamination group, with the incidence rate in the non-decontamination group significantly higher than that in the decontamination group (P < 0.001). Only 10 cases of infections were identified as p-DDI, all of which were positive for preservation solution culture, including 8 cases in the non-decontamination group and 2 cases in the decontamination group (P < 0.05). There were 5 cases of p-DDI related to MDR GNB in the non-decontamination group, while no such cases occurred in the decontamination group (P < 0.05). No adverse reactions related to polymyxin B were observed, and no recipient death or renal allograft dysfunction occurred in either group. Conclusions Adding polymyxin B to the preservation fluid during hypothermic machine perfusion with LifePort before renal transplantation may reduce p-DDI and its potential adverse consequences.
