Clinical research progress on cell therapy induced immune tolerance in liver transplantation
10.12464/j.issn.1674-7445.2025248
- VernacularTitle:细胞治疗诱导肝移植免疫耐受临床研究进展
- Author:
Chenliang SHAO
1
;
Li PANG
1
;
Chao LIU
1
;
Leibo XU
1
Author Information
1. Department of Biliary and Pancreatic Surgery (Liver Transplantation Center), Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
- Publication Type:TransplantationForefront
- Keywords:
Liver transplantation;
Immune tolerance;
Rejection;
Cell therapy;
Regulatory T cell;
Regulatory dendritic cell;
Mesenchymal stem cell;
Hematopoietic stem cell
- From:
Organ Transplantation
2026;17(2):205-211
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is the preferred treatment for end-stage liver disease, but recipients require long-term immunosuppressive therapy to control rejection, which may lead to complications and affect their long-term survival. Immune tolerance refers to the ability of organ transplant recipients to maintain their immune system's tolerance to the graft without relying on long-term immunosuppressants. Immune tolerance is an ideal goal pursued in the field of organ transplantation, which can reduce adverse drug reactions and improve long-term survival rates. Cell therapy has emerged as a promising strategy to induce such tolerance after liver transplantation. Therefore, this article reviews the application progress of cell therapies such as regulatory T cells, regulatory dendritic cells, mesenchymal stem cells, hematopoietic stem cells, etc. in inducing immune tolerance after liver transplantation, in order to provide reference for the clinical application of immune tolerance induction after liver transplantation.
