Application of new antibiotics in the treatment of drug-resistant bacteria infections after solid organ transplantation
10.12464/j.issn.1674-7445.2026031
- VernacularTitle:新型抗生素在实体器官移植耐药菌感染治疗中的应用
- Author:
Chunrong JU
1
;
Xiao XU
2
;
Wujun XUE
2
Author Information
1. Department of Organ Transplantation, the First Hospital of Guangzhou Medical University, Guangzhou 510120, China.
2. null.
- Publication Type:Editorial
- Keywords:
New antibiotic;
Organ transplantation;
Immunosuppression;
New β-lactam/β-lactamase inhibitor combination preparation;
New aminoglycoside;
Tetracycline;
Oxazolidinone;
Iron carrier cephalosporin
- From:
Organ Transplantation
2026;17(2):182-191
- CountryChina
- Language:Chinese
-
Abstract:
Solid organ transplantation (SOT) is an effective treatment method for various end-stage diseases. However, due to the need for long-term use of immunosuppressive drugs to prevent rejection reactions after the surgery, SOT recipients are generally in a state of low immune function, resulting in a significant increase in the risk of infection. Post-transplant infection, especially infections caused by multi-drug resistant bacteria, is one of the common complications for SOT recipients and is also a major cause of graft dysfunction, graft loss and even death of the recipients. As the global situation of bacterial resistance becomes increasingly severe, the burden of infectious diseases continues to increase, seriously threatening the survival prognosis and graft function of SOT recipients. The exploration of new antibiotic research and rational application strategies worldwide has become crucial. The development and launch of various new antibiotics have provided more options for clinical practice. Therefore, systematically reviewing the drug characteristics of new antibiotics and their application status in this special population of SOT recipients is of great significance for guiding clinical practice and improving patients’ prognosis.
