Research progress on the mechanisms of Tibetan medicine Gentianopsis paludosa and its chemical components against ulcerative colitis and associated fibrosis
- VernacularTitle:藏药湿生扁蕾及其活性成分抗溃疡性结肠炎及相关纤维化的机制研究进展
- Author:
Huan LI
1
;
Qing NIE
2
;
Yongkang AN
1
;
Shuangxi ZHANG
1
;
Xiang’an ZHANG
1
Author Information
1. Dept. of Anorectology，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
2. The Fifth Clinical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
Gentianopsis paludosa;
ulcerative colitis;
intestinal fibrosis;
xanthones;
flavonoids;
active ingredient;
mechanism
- From:
China Pharmacy
2026;37(5):676-681
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a chronic and relapsing inflammatory disease of the intestine. Intestinal fibrosis represents a severe co mplication and a potential risk factor for malignant transformation. Gentianopsis paludosa is one of the traditional Tibetan medicines commonly used for treating gastrointestinal disorders such as damp-heat diarrhea and dysentery. Its chemical composition is complex， encompassing xanthones， flavonoids， terpenoids， and other bioactive components， and it exhibits properties such as clearing heat， eliminating dampness， and detoxifying. This article reviews the research progress on the pharmacodynamic material basis and mechanisms of G. paludosa against UC and associated fibrosis. Findings suggest that its extracts （e.g.， aqueous extract， ethyl acetate extract） and active constituents （e.g.， 1-hydroxy-3，7，8-trimethoxyxanthone， ursolic acid， swertiamarin， luteolin） may inhibit inflammatory cytokines， combat oxidative stress， suppress cell apoptosis， regulate intestinal microbiota and their metabolites， protect the intestinal mucosal barrier， modulate immune responses， and inhibit epithelial-mesenchymal transition， through modulating relevant signaling pathways， such as nuclear factor-kappa B， B-cell lymphoma-2 （Bcl-2）/Bcl-2-associated X protein， and transforming growth factor-β 1 /Smad， thus exerting therapeutic effects against UC and its related fibrosis via these seven aspects.
