Research progress on the intervention of energy metabolism disorders in chronic heart failure by active ingredients of traditional Chinese medicine through regulating circadian rhythms
- VernacularTitle:中药有效成分调节生物钟节律干预慢性心力衰竭能量代谢障碍的研究进展
- Author:
Ruiqi GUO
1
;
Sutong WANG
2
;
Zhaohui LYU
2
;
Yan LI
2
;
Renwei GUAN
3
;
Xiao LI
4
Author Information
1. The First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan 250355，China;Shandong Academy of Chinese Medicine，Jinan 250014，China;State Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs，Beijing 100700，China
2. The First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
3. Shandong Academy of Chinese Medicine，Jinan 250014，China
4. Dept. of Cardiology，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250014，China
- Publication Type:Journal Article
- Keywords:
circadian rhythms;
chronic heart failure
- From:
China Pharmacy
2026;37(5):670-675
- CountryChina
- Language:Chinese
-
Abstract:
The onset and progression of chronic heart failure （CHF） are closely associated with myocardial energy metabolism disorders， and this pathological process significantly affects patient prognosis. Traditional Chinese medicine （TCM）， grounded in time-based medical theories such as the correspondence between humans and nature and the theory of circadian flow of meridians （Ziwu Liuzhu）， exhibits intrinsic consistency with modern circadian rhythm theory， providing a unique theoretical framework for understanding and intervening in CHF from a temporal perspective. This article systematically explores the impact of circadian rhythms on energy metabolism and the potential mechanisms by which TCM active ingredients intervene in CHF through a review of relevant literature. It is found that various TCM active ingredients， including flavonoids （such as nobiletin）， alkaloids （such as berberine）， and polyphenols （such as resveratrol）， can improve mitochondrial function， promote fatty acid oxidation， enhance glucose uptake and utilization efficiency， maintain metabolic balance， and alleviate oxidative stress and inflammatory responses in myocardial cells by regulating the expression and rhythms of core circadian clock genes such as CLOCK， BMAL1， PER， and CRY. These actions thereby correct energy metabolism disorders and improve cardiac function. Further exploration of the interaction mechanisms between these components and the circadian rhythms holds promise for providing novel theoretical foundations and potential intervention strategies for the prevention and treatment of CHF.
