Mechanisms and treatments of cognitive decline induced by cranial radiation
10.13491/j.issn.1004-714X.2026.01.021
- VernacularTitle:颅脑辐射诱发认知功能损伤的机制及治疗分析
- Author:
Yifan HU
1
;
Wenjing YANG
2
;
Shufang CUI
2
;
Xiaoying BI
3
Author Information
1. Department of Neurology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, China;No. 904 Hospital Changzhou Medical District of the PLA Joint Logistics Support Force, Changzhou 213000, China.
2. Laboratory Animal Science Department, Basic Medical School, Naval Medical University, Shanghai 200433, China.
3. Department of Neurology, The First Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200433, China.
- Publication Type:ReviewArticles
- Keywords:
Craniocerebral radiotherapy;
Cognitive function;
Neurogenesis;
Neuron;
Glial cell;
Therapy
- From:
Chinese Journal of Radiological Health
2026;35(1):128-135
- CountryChina
- Language:Chinese
-
Abstract:
While cranial radiotherapy effectively kills tumor cells and significantly prolongs patient survival, it often leads to progressive cognitive decline. To date, the specific mechanisms underlying radiation-induced cognitive decline have not been fully elucidated, which greatly limits the development of related therapeutic strategies. Therefore, this article provides a comprehensive analysis of post-radiation changes in neurogenesis, neuronal synaptic plasticity, myelin injury plasticity, and parenchymal cells such as microglia in the brain, systematically elucidates the potential mechanisms of radiation-induced cognitive decline, and summarizes feasible therapeutic approaches. These findings provide a solid foundation for developing novel strategies to mitigate radiation-induced cognitive decline.
