Research progress on cell membrane biomimetic nanoparticles for delivery of antitumor natural products
- VernacularTitle:细胞膜仿生纳米粒递送抗肿瘤天然产物的研究进展
- Author:
Luhua MENG
1
;
Hong PAN
1
;
Shuhuan LIU
1
;
Mengmeng SHEN
1
Author Information
1. National Drug Clinical Trial Center Office，Affiliated Hospital of Jining Medical University，Shandong Jining 272000，China
- Publication Type:Journal Article
- Keywords:
cell membrane;
biomimetic nanoparticles;
natural products;
antitumor;
drug delivery system
- From:
China Pharmacy
2026;37(4):547-552
- CountryChina
- Language:Chinese
-
Abstract:
Natural products have shown great potential in the research and development of antitumor drugs. However， their clinical application is severely limited by inherent drawbacks such as poor water solubility， low stability， and low bioavailability. Cell membrane biomimetic nanoparticles， as a novel drug delivery system， have provided new strategies to overcome this bottleneck. This review systematically summarizes the preparation methods （e.g.， membrane extrusion， ultrasonic fusion， and microfluidic electroporation） and characterization techniques （e.g.， particle size， Zeta potential， and membrane surface protein detection） of cell membrane biomimetic nanoparticles， with a focus on the application of these derived from various sources in delivering antitumor natural products. Cell membrane biomimetic nanoparticles are endowed with unique biological functions， including low immunogenicity conferred by stem cell membranes， prolonged systemic circulation enabled by red blood cell membranes， and homologous targeting facilitated by tumor cell membranes. Despite these advancements， the technology still faces challenges such as difficulties in large-scale production， high costs， and limited characterization methods. Future research needs to further optimize the relevant processes to promote the clinical translation of cell membrane-biomimetic nanoparticles， thereby offering an efficient and safe novel delivery approach for antitumor therapy using natural products.
