Research progress on the molecular mechanisms of traditional Chinese medicine monomers in ameliorating renal ischemia-reperfusion injury
- VernacularTitle:中药单体改善肾缺血再灌注损伤的分子机制研究进展
- Author:
Jinrui HUANG
1
;
Wei LIU
1
;
Jinhui WEI
2
;
Yubo CHANG
1
;
Hongbin MA
2
Author Information
1. School of Graduate，Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Dept. of Nephrology，Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
renal ischemia-reperfusion injury;
traditional Chinese medicine monomers;
pathway;
oxidative stress;
acute kidney
- From:
China Pharmacy
2026;37(4):540-546
- CountryChina
- Language:Chinese
-
Abstract:
Renal ischemia-reperfusion injury （RIRI） is a major cause of acute kidney injury during kidney transplantation and peri-operative settings， and there is still a lack of safe and effective targeted preventive and therapeutic drugs in clinical practice. Specifically， xanthohumol， luteolin， dracorhodin C， naringin， senkyunolide Ⅰ， verbascoside， and shikonin enhance antioxidant defenses， and inhibit lipid peroxidation and ferroptosis via the nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 pathway. Apigenin， nobiletin， tanshinone Ⅱ A ， and salidroside activate the phosphatidylinositol 3-kinase/protein kinase B pathway to inhibit mitochondria- dependent apoptosis and facilitate renal repair. Quercetin， methyleugenol， cyanidin-3-glucoside， and platycodin D promote autophagy and improve mitochondrial homeostasis through the adenosine monophosphate-activated protein kinase（AMPK）/mTOR or AMPK/phosphatase and tensin homolog-induced kinase 1/Parkin pathways. In addition， hesperidin， curcumin， ganoderic acid， pulsatilla saponin B4， capsaicin， and diosgenin mitigate inflammatory responses and decrease renal tubular injury markers by inhibiting the Toll-like receptor 4/nuclear factor κB， high mobility group box 1， Janus kinase/signal transducer and activator of transcription pathways， thereby exerting multi-target， multi-stage renoprotective effects.
