Research progress on the intervention of traditional Chinese medicine in lipid metabolism for obesity treatment via cAMP signaling pathway
- VernacularTitle:中药调控cAMP信号通路干预脂质代谢治疗肥胖的研究进展
- Author:
Yu ZHANG
1
;
Xiaoran WANG
1
;
Yiping FU
1
;
Yuting LIU
1
;
Quanyou ZHAO
1
;
Linna CUI
1
;
Mingsan MIAO
1
Author Information
1. Academy of Chinese Medical Sciences，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
obesity;
lipid metabolism;
cAMP signaling pathway;
mechanism;
traditional Chinese medicine
- From:
China Pharmacy
2026;37(4):522-527
- CountryChina
- Language:Chinese
-
Abstract:
Obesity， a global chronic disease， is associated with adipose tissue dysfunction， which is one of the contributing factors to obesity. The cyclic adenosine monophosphate （cAMP） signaling pathway， a key regulator of lipid metabolism， plays a pivotal role in obesity development. Various of traditional Chinese medicine monomers， such as flavonoids， lignans， phenols， and terpenoids， as well as traditional Chinese medicine compound formulas like Xiaoyao powder， Shengmai powder， and Zexie decoction， can maintain energy homeostasis， balance adipose tissue function， regulate glucose metabolism， improve insulin resistance， and suppress inflammatory responses through cAMP signaling pathway regulation， thereby intervening in lipid metabolism for obesity treatment. Although a substantial amount of basic research has preliminarily elucidated the potential mechanisms by which traditional Chinese medicine intervenes in obesity through the cAMP signaling pathway， clinical translational research remains inadequate. There is an urgent need for large-sample， high-quality randomized controlled trials to validate these findings.
