Research progress on traditional Chinese medicine in the treatment of sepsis by regulating helper T cell differen-tiation
- VernacularTitle:中药调节辅助性T细胞分化治疗脓毒症的研究进展
- Author:
Sihan GUO
1
;
He SU
2
;
Ruifen ZHANG
3
;
Tingting JIA
3
;
Hairong ZHANG
3
;
Jilintai RONG
1
Author Information
1. School of Traditional Chinese Medicine，Inner Mongolia Medical University，Hohhot 010000，China
2. School of Traditional Chinese Medicine，Inner Mongolia Medical University，Hohhot 010000，China;Dept. of Critical Care Medicine，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010000，China
3. Dept. of Critical Care Medicine，Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine，Hohhot 010000，China
- Publication Type:Journal Article
- Keywords:
sepsis;
helper T cell;
regulatory T cells;
immune balance;
traditional Chinese medicine;
cell differentiation
- From:
China Pharmacy
2026;37(4):516-521
- CountryChina
- Language:Chinese
-
Abstract:
epsis is a systemic inflammatory response syndrome triggered by infection， and its high mortality rate is closely associated with immune imbalance， particularly the imbalance in the differentiation of helper T cell （Th） cell subsets [Th1， Th2， Th17， regulatory T cell （Treg） ] . In recent years， traditional Chinese medicine （TCM）， with its characteristics of multi-component and multi-target actions， has demonstrated unique advantages in regulating Th cell differentiation and function， as well as correcting immune imbalances in sepsis， offering new perspectives for immunotherapy of sepsis. This review summarizes relevant studies on the regulation of Th cell differentiation for sepsis treatment by TCM monomers and active ingredients （such as Astragalus membranaceus ， Scutellaria baicalensis ， Coptis chinensis ， Rheum palmatum ， Ganoderma lucidum ， Ginkgo biloba ， and Cistanche deserticola ）， the alcohol extract of Dai Baijie， and TCM formulas and preparations categorized as blood-activating and stasis-removing， purgative and laxative， warming and tonifying yang， and tonifying qi and nourishing yin. The results indicate that these TCM monomers， active ingredients， extracts， formulas， and preparations can regulate the Th1/Th2 and Th17/Treg balance， target the differentiation balance of Th cell subsets， alleviate inflammatory responses， or improve immune suppression， thereby exerting therapeutic effects on sepsis.
