Traditional Chinese Medicine in Regulation of Relevant Signaling Pathways for Glaucoma Treatment： A Review
10.13422/j.cnki.syfjx.20251306
- VernacularTitle:中药治疗青光眼相关信号通路的研究进展
- Author:
Weiwen QIU
1
;
Xueqin HE
1
;
Xinbei LIN
2
;
Lianxiang LUO
2
;
Qiuli ZHANG
1
Author Information
1. Affiliated Hospital of Guangdong Medical University，Zhanjiang 524001，China
2. School of Marine and Tropical Medicine，Guangdong Medical University，Zhanjiang 524001，China
- Publication Type:Journal Article
- Keywords:
glaucoma;
Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB （TLR4/MyD88/NF-κB） signaling pathway;
Janus kinase （JAK）/signal transducer and activator of transcription （JAK/STAT） signaling pathway;
phosphoinositide 3-kinase/serine-threonine protein kinase/mammalian target of rapamycin （PI3K/Akt/mTOR） signaling pathway;
nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） signaling pathway;
nuclear factor erythroid 2-related factor 2/heme oxygenase-1 （Nrf2/HO-1） signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(1):338-346
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma， characterized by pathological elevation of intraocular pressure， progressive optic nerve damage， and apoptosis of retinal ganglion cells， is one of the leading causes of irreversible blindness. It is strongly associated with significant vision loss and a decline in quality of life. Although pharmacological therapy remains the primary approach to managing glaucoma， clinical outcomes are often suboptimal， highlighting the urgent need for safe and effective alternative treatments. In traditional Chinese medicine （TCM）， glaucoma is categorized as part of the "five wind internal obstruction" syndrome， and TCM has amassed substantial experience in the prevention and treatment of this condition. Therefore， this article provided a comprehensive review of recent findings on the relationship between glaucoma and relevant signaling pathways， as well as the regulatory effects of TCM on these pathways in the treatment of glaucoma. TCM can exert therapeutic effects by modulating key signaling pathways， including the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB （TLR4/MyD88/NF-κB） signaling pathway， Janus kinase （JAK）/signal transducer and activator of transcription （JAK/STAT） pathway， phosphoinositide 3-kinase/serine-threonine protein kinase/mammalian target of rapamycin （PI3K/Akt/mTOR） pathway， nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） inflammasome pathway， and nuclear factor erythroid 2-related factor 2/heme oxygenase-1 （Nrf2/HO-1） pathway. These pathways are involved in reducing inflammation， inhibiting apoptosis and ferroptosis， and ameliorating oxidative stress. By synthesizing current research， this article offers theoretical insights and practical references for advancing the understanding of the pathological mechanisms underlying glaucoma， innovating strategies for optic nerve protection， and promoting integrative TCM and Western medical approaches in glaucoma management.
