Pharmacological Effect and Preparation Development of Geniposide： A Review
10.13422/j.cnki.syfjx.20251037
- VernacularTitle:栀子苷的药理作用及制剂开发研究进展
- Author:
Yongmei GUAN
1
;
Yidan LIU
1
;
Hua ZHANG
2
;
Haiyan ZHANG
1
;
Zhenzhong ZANG
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine（TCM）， Ministry of Education， Jiangxi University of Chinese Medicine， Nanchang 330004，China
2. School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
geniposide;
hepatoprotection;
anti-inflammatory and analgesic;
neuroprotection;
formulation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(1):317-326
- CountryChina
- Language:Chinese
-
Abstract:
Geniposide， the primary active component of the traditional Chinese medicine Gardeniae Fructus， is a water-soluble iridoid glycoside. Pharmacological studies have demonstrated that geniposide exhibits various biological activities， including hepatoprotective， anti-inflammatory， analgesic， neuroprotective， antidepressant effects， and inhibitory activity against ischemia-reperfusion injury. Recent research has revealed its promising potential in preventing and treating diseases such as atherosclerosis and osteoporosis， indicating broad application prospects. Numerous in vitro and in vivo studies indicate that the pharmacodynamic mechanisms of geniposide are primarily associated with the inhibition of inflammatory responses and oxidative stress， improvement of lipid metabolism， and regulation of apoptosis. However， due to its high water solubility and rapid metabolism in vivo， geniposide suffers from low oral bioavailability， which limits its therapeutic efficacy and clinical application. In recent years， various formulations， such as creams， cubic liquid crystals， hydrogels， and liposomes， have been developed to address its bioavailability issues. This article reviewed the latest research progress on the pharmacological activities and formulation development of geniposide by analyzing domestic and international literature from the past decade， aiming to provide a theoretical basis for further research， development， and utilization of geniposide and its formulations.
