Microscopic Mechanism of Ulcerative Colitis and New Ideas on Medicine Management Based on Theory of Mutual Interference Between Lucidity and Turbidity
10.13422/j.cnki.syfjx.20251996
- VernacularTitle:基于“清浊相干”理论探析溃疡性结肠炎的微观机制及理药思辨
- Author:
Yuying XU
1
;
Changpu ZHAO
1
;
Lei LUO
2
;
Renwu CHEN
1
;
Zishun LI
1
;
Meiling LI
1
;
Rongzhi LI
1
;
Yu ZHANG
1
;
Guangjie SHU
3
Author Information
1. The Second Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450000，China
2. Henan Province Hospital of Chinese Medicine， Zhengzhou 450000，China
3. Zhengzhou University，Zhengzhou 450053，China
- Publication Type:Journal Article
- Keywords:
mutual interference between lucidity and turbidity;
ulcerative colitis;
micro-mechanism;
ideas on medicine management
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(1):288-299
- CountryChina
- Language:Chinese
-
Abstract:
The chapter Zhouyu in Guoyu says "Qi of the heaven and the earth moves without losing its order." With lucidity ascending and turbidity descending， Qi moves in a normal state， and Yin and Yang consolidate the foundation of the body. The mutual interference between lucidity and turbidity leads to the disorder of Qi movement， thus causing diseases. It is a pathological state of disorder between ascending and descending， as well as between entering and exiting， gradually evolving into a state of turbidity affecting lucidity and transforming into pathogen， which can be used to interpret and analyze the core of disease pathogenesis. The theory of lucidity and turbidity is connected with the harmony of nutrient and defensive aspects， Qi circulation， and sweat pore associating with Qi movement， and it has common implications with immune responses and nutrient metabolism system， intestinal mucosal barrier function， and mitochondrial energy synthesis. Modern studies have shown that intestinal flora imbalance， bile acid receptor inactivation， macrophage polarization imbalance， epithelial-mesenchymal transition， ferroptosis and other related microscopic pathological mechanisms are involved in the development and progression of ulcerative colitis. By delving into the common meaning of the classic theory of mutual interference between lucidity and turbidity in traditional Chinese medicine and modern medical pathological mechanisms， this paper summarizes the correspondence between the micropathological mechanism and the theory of mutual interference between lucidity and turbidity in the regulation and mamagement of ulcerative colitis. The combined use of sweet and warm medicinal materials consolidates the middle Qi and activates Qi circulation， thus ascending lucidity and descending turbidity. The combined use of pungent medicinal materials for dispersing and bitter medicinal materials for descending simultaneously raises warm and clear Qi. Wind-extinguishing medicinal materials facilitate the ascending of Qi and the opening of sweat pores. Accordingly， turbidity descends and lucidity ascends. The prescriptions incorporating these medication principles are in agreement with the therapeutic approach of following the normal flow of lucidity and turbidity. This paper clarifies the scientific connotation and micropathologic mechanism of ulcerative colitis from the perspective of mutual interference between lucidity and turbidity， providing new theories and prescriptions for the clinical diagnosis， treatment， and prevention of ulcerative colitis.
