Research advances on centromere proteins shaping immunosuppressive tumor microenvironment to promote immune escape
- VernacularTitle:着丝粒蛋白塑造免疫抑制性肿瘤微环境 促进免疫逃逸的研究进展
- Author:
Suqin Wang
1
;
Jiayan Tan
1
;
Ya Li
1
Author Information
- Publication Type:Review
- Keywords: cancer; centromere proteins; tumor microenvironment; immune evasion; immunosuppression; metabolic reprogramming
- From: Acta Universitatis Medicinalis Anhui 2025;60(10):1975-1979
- CountryChina
- Language:Chinese
- Abstract: Abstract:Tumor immune escape represents a pivotal determinant of cancer immunotherapy failure. It's mechanistically linked to immunosuppressive tumor microenvironment(TME). The TME comprises tumor cells, immune cells, stromal components and extracellular matrix. These components interact synergistically to suppress antitumor immunity through multiple pathways, thereby promoting immune evasion. As crucial chromosomal stability regulators, centromere proteins(CENPs) remodel the TME via multifaceted mechanisms to potentiate immune evasion. This review synthesizes current knowledge on CENPs' role in tumor immune evasion, offering novel insights for cancer diagnostics and immunotherapy.
- Full text:2026031023565375824着丝粒蛋白塑造免疫抑制性肿瘤微环境促进免疫逃逸的研究进展_王夙琴.pdf
