Research progress on application of cell co-culture technology in respiratory diseases
10.19405/j.cnki.issn1000-1492.2025.10.026
- VernacularTitle:细胞共培养技术在呼吸系统疾病研究中的应用
- Author:
Yuwei Song
1
;
Jingfan Yang
1
;
Haibo Li
1
;
Yanqin Qin
2
Author Information
1. Henan University of Chinese Medicine ,Henan Key Laboratory of Chinese Medicine for Respiratory Disease , Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-Constructed by Henan Province & Education Ministry of P. R. China ,Zhengzhou 450046
2. Henan University of Chinese Medicine ,Henan Key Laboratory of Chinese Medicine for Respiratory Disease , Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-Constructed by Henan Province & Education Ministry of P. R. China ,Zhengzhou 450046 ; Academy of Chinese Medical Sciences ,Henan University of Chinese Medicine , Zhengzhou 450046
- Publication Type:Review
- Keywords:
cell co-culture;
respiratory diseases;
cellular crosstalk;
cellular microenvironment;
in vitro models
- From:
Acta Universitatis Medicinalis Anhui
2025;60(10):1969-1974
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Respiratory diseases represent prevalent conditions that pose a significant threat to public health. The pathogenesis of these diseases is complex involving a variety of cells and cytokines. Cell culture technology serves as a fundamental tool for investigating pathological mechanisms and drug efficacy. However, traditional monolayer cell culture fail to mimic the intricate cell-cell interactions, limiting its applicability. In contrast, cell co-culture offers a more physiologically relevant approach by closely mimicking the multicellular microenvironment. This advancement provides a robust model for elucidating pathological pathways and evaluating pharmacological interventions in respiratory diseases. In this review, the applications of cell co-culture technologies in common respiratory diseases, including chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, lung cancer, asthma, and pneumonia are summarized, in order to propose strategies for the prevention and treatment of these diseases.
- Full text:2026031023530119569细胞共培养技术在呼吸系统疾病研究中的应用_宋雨薇.pdf
