An association study between ALOX15 gene polymorphisms and non-cardia gastric carcinogenesis
10.19405/j.cnki.issn1000-1492.2025.10.012
- VernacularTitle:ALOX15 基因多态性与非贲门胃癌变的关联研究
- Author:
Ning Chu
1
;
Wenjie Dong
2
;
Fang Gao
3
;
Yingze Li
4
;
Yaru Chen
2
;
Bin Zhang
5
;
Yanbin Jia
2
Author Information
1. School of Basic Medicine and Forensic Medicine , Baotou Medical College , Baotou 014040 ; Dept of Clinical Laboratory, The Second Afiliated Hospital of Baotou Medical College , Baotou 014030
2. School of Basic Medicine and Forensic Medicine , Baotou Medical College , Baotou 014040
3. School of Medical Technology and Anaesthesia , Baotou Medical College , Baotou 014040
4. Dept of Clinical Laboratory, Baotou Tumor Hospital , Baotou 014030
5. Dept of Endocrinology, The First Afiliated Hospital of Baotou Medical College , Baotou 014010
- Publication Type:Journal Article
- Keywords:
non-cardia gastric cancer;
Helicobacter pylori;
arachidonate15-lipoxygenase;
single nucleotide polymorphism;
genetic susceptibility;
association study
- From:
Acta Universitatis Medicinalis Anhui
2025;60(10):1865-1873
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between single nucleotide polymorphism(SNP) in the arachidonate 15-lipoxygenase(ALOX15) gene and Helicobacter pylori(H. pylori) infection as well as the risk of non-cardia gastric cancer in Baotou Han population, and to provide experimental evidence and data support for the screening of susceptible population for non-cardia gastric cancer.
Methods:A total of 458 cases with non-cardia gastric cancer and 460 healthy examination people were collected. The 14C urea breath test(UBT) and enzyme-linked immunosorbent assay(ELISA) were used to detect H. pylori infection in the 460 healthy individuals. The genotypes of ALOX15 rs2619112, rs2619118, rs2664593, rs7220870 were detected by polymerase chain reaction-restriction fragment length polymorphism, and the association of SNP with H. pylori infection as well as the risk of non-cardia gastric cancer was statistically analyzed.
Results:The positive rate of H. pylori infection was 42.4%. ALOX15 rs2619112, rs2619118, rs2664593, and rs7220870 had no association with H. pylori infection. ALOX15 rs2619112, rs2664593, and rs7220870 were not associated with the risk of non-cardia gastric cancer. Compared with the carriers of(CC + CT) genotype, the carriers of rs2619118 TT genotype had an increased onset risk of non-cardia gastric cancer [OR(95%CI)=1.512(1.110-2.060)]. The haplotype ACCC constructed by ALOX15 rs2619112, rs2619118, rs2664593, and rs7220870 could reduce the onset risk of non-cardia gastric cancer. The second-order interaction of ALOX15 rs2619112 and rs2619118 was associated with the risk of non-cardia gastric cancer ( P < 0. 05 ) .
Conclusion:ALOX15 rs2619112 , rs2619118 , rs2664593 , rs7220870 may not play a major role in H. pylori infection. ALOX15 rs2619118 TT genotype is a risk factor for the development of non⁃cardia gastric cancer. The haplotype ACCC constructed by ALOX15 rs2619112 , rs2619118 , rs2664593 , and rs7220870 reduces the onset risk of non⁃cardia gastric cancer. The interaction of ALOX15 rs2619112 and rs2619118 has a synergistic effect in the development of non⁃cardia gastric cancer.
- Full text:2026030923465969564ALOX15基因多态性与非贲门胃癌变的关联研究_褚宁.pdf
