Research on the effect of miHA-TM in enhancing donor bone marrow transplantation outcomes under low-intensity conditioning
10.19405/j.cnki.issn1000-1492.2025.10.001
- VernacularTitle:miHA⁃TM 在低强度预处理下改善供体骨髓移植的效果研究
- Author:
Yajing Pu
1
;
Meng Zhou
1
Author Information
1. College of Life Sciences , Anhui Medical University, Hefei 230032
- Publication Type:Journal Article
- Keywords:
allogeneic hematopoietic stem cell transplantation;
pre-transplantation conditioning;
minor histocompatibility antigen;
hematological diseases;
graft-versus-host disease;
central memory T cells
- From:
Acta Universitatis Medicinalis Anhui
2025;60(10):1775-1780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To treat malignant and non-malignant hematological diseases, allogeneic hematopoietic stem cell transplantation(alloSCT) is widely used. However, its application is limited by the risk of graft-versus-host disease(GVHD), difficulties in donor matching, and the high incidence of transplantation-related mortality due to myeloablative conditioning regimens. Therefore, there is an urgent need to develop new strategies that reduce the intensity of conditioning while enhancing donor engraftment efficiency.
Methods:In an alloSCT model, minor histocompatibility antigen-specific donor central memory T cells(miHA-TM) combined with a CD40 agonist were adoptively transferred to evaluate donor bone marrow engraftment under different irradiation doses.
Results:Minor histocompatibility antigen(miHA)-specific donor-derived central memory T cells(TM) facilitated recipient immune reconstitution without inducing GVHD. Donor-derived TM cells, however, underwent exhaustion during the process of recipient immune reconstitution, which compromised complete donor engraftment under reduced-intensity conditioning. At a low irradiation dose(4 Gy), the combination of miHA-TM and a CD40 agonist significantly promoted donor bone marrow engraftment.
Conclusion:miHA-TM facilitates immune reconstitution in recipients without inducing graft-versus-host disease.
- Full text:2026030719260144485miHA-TM在低强度预处理下改善供体骨髓移植的效果研究_蒲雅静.pdf
