Correlation analysis of inflammatory markers （NLR/PLR/SII） with the severity of intrauterine adhesions
- VernacularTitle:炎症指标（NLR/PLR/SII）与宫腔粘连严重程度的相关性分析
- Author:
Ying WANG
1
;
Xuan XU
1
;
Longyu ZHANG
1
;
Rong WU
1
;
Jingjing HU
1
;
Wenjuan YANG
1
;
Xiao WU
1
;
Zhaolian WEI
1
Author Information
- Publication Type:Journal Article
- Keywords: intrauterine adhesion; transcervical resection of adhesions; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammation index
- From: Acta Universitatis Medicinalis Anhui 2026;61(1):146-150
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo investigate the correlation between neutrophil-to-lymphocyte ratio （NLR）， platelet-to-lymphocyte ratio （PLR）， systemic immune-inflammation index （SII） and the severity of intrauterine adhesions （IUA）. MethodsThe retrospective study included 380 patients who underwent transcervical resection of adhesions （TCRA） from December 2019 to March 2025. Based on the American Fertility Society （AFS） classification， patients were divided into mild （n=61）， moderate （n=225）， and severe （n=94） groups. NLR， PLR， and SII were calculated from preoperative blood tests. Statistical analyses included Kruskal-Wallis test and ordinal Logistic regression. ResultsNLR， PLR， and SII were significantly higher in the severe IUA group compared to the mild group （P<0.05）， with SII showing the strongest predictive ability （OR=1.004， P=0.001）. The number of intrauterine procedures was an independent risk factor （OR=1.27/level， P=0.016）. The predictive model ［Logit（P）=-0.676+0.241×operation times+0.004×SII］ effectively identified severe IUA cases. ConclusionInflammatory markers （particularly SII） are correlated with IUA severity and may serve as non-invasive tools for clinical assessment.
