The Mechanism of Glutamine activating autophagy exacerbates muscle loss in cancer-associated cachexia
10.19405/j.cnki.issn1000-1492.2025.11.026
- VernacularTitle:谷氨酰胺调控自噬在肿瘤恶病质骨骼肌中的作用机制
- Author:
Dufang Ma
1
;
Yong Wang
2
;
Zhihan Tian
3
;
Xiaoyu Su
3
;
Yuanfu Qi
4
Author Information
1. The First School of Clinical Medicine , Shandong University of Traditional Chinese Medicine , Jinan 250014;Cardiovascular Disease Diagnosis and Treatment Center ,Afiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan 250014
2. Cardiovascular Disease Diagnosis and Treatment Center ,Afiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan 250014
3. The First School of Clinical Medicine , Shandong University of Traditional Chinese Medicine , Jinan 250014
4. Dept of Oncology , Afiliated Hospital of Shandong University of Traditional Chinese Medicine , Jinan 250014
- Publication Type:Review
- Keywords:
cancer-associated cachexia;
skeletal muscle wasting;
glutamine;
autophagy;
mammalian target of rapamycin complex 1;
AMP-activated protein kinase
- From:
Acta Universitatis Medicinalis Anhui
2025;60(11):2182-2186
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Cachexia is one of the serious complications in patients with end-stage cancer.Progressive depletion of skeletal muscle is an important feature of cachexia.Previous studies have found that excessive activation of autophagy accelerates skeletal muscle wasting in cachexia,and glutamine released from excessive catabolism of muscle tissue can trigger the autophagy.Mammalian target of rapamycin complex 1(mTORC1) and AMP-activated protein kinase(AMPK) signaling regulate autophagy genesis;moreover,glutamine regulates the mTORC1 and AMPK signaling pathways.Therefore,it is deduced that higher level of glutamine may result in abnormal autophagy by regulating mTORC1 and AMPK in cancer cachexia,which contributes to the development of skeletal muscle wasting.Here,this review discusses the following three perspectives:firstly,autophagy hyperactivation is involved in skeletal muscle wasting in cancer cachexia.Secondly,how mTORC1 and AMPK signaling pathways regulate autophagy.Finally,glutamine is involved in skeletal muscle wasting in cancer cachexia by induced autophagy hyperactivation via regulating mTORC1/AMPK signaling.Our study will provide a scientific basis for the development of potential therapeutic strategies.
- Full text:2026030523055338036谷氨酰胺调控自噬在肿瘤恶病质骨骼肌中的作用机制_马度芳.pdf
