The relationship between ectopic fat and iron deposition in muscle and glucose metabolism in patients with elderly obese patients
10.19405/j.cnki.issn1000-1492.2025.11.019
- VernacularTitle:肌肉脂肪及铁沉积与老年肥胖患者糖代谢的关系
- Author:
Hao Nie
1
;
Min Liu
2
;
Junhong Duan
3
;
Hong Liu
2
Author Information
1. Dept of Geriatrics , Hunan Provincial People ′s Hospital , The First Afiliated Hospital of Hunan Normal University , Changsha 410005
2. Dept of Nutrition ,the Third Xiangya Hospital of Central South University , Changsha 410013
3. Dept of Radiology , the Third Xiangya Hospital of Central South University , Changsha 410013
- Publication Type:Journal Article
- Keywords:
obesity;
magnetic resonance imaging;
muscle fat deposition;
muscle iron deposition;
elderly type 2 diabetes mellitus;
abnormal glucose metabolism
- From:
Acta Universitatis Medicinalis Anhui
2025;60(11):2131-2136
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between muscle fat deposition , muscle iron deposition , and glu- cose metabolism in elderly obese patients .
Methods:Elderly obese patients who visited the outpatient clinic were selected . Oral glucose tolerance tests were performed . Muscle fat and iron deposition in the abdominal wall and pa- raspinal muscles at the L3 vertebra level were quantified using the Dixon technique based on nuclear magnetic reso- nance .
Results:A total of 140 elderly obese patients were included , among which 46 were newly diagnosed with type 2 diabetes mellitus (T2DM) , 44 had impaired glucose tolerance (IGR) , and 50 had normal glucose tolerance (NGT) . Compared to NGT and IGR groups , patients with T2DM had significantly increased muscle fat deposition , iron deposition , and visceral fat , while subcutaneous fat was significantly reduced (P < 0. 05) . After adjusting for confounding factors using multivariate logistic regression , muscle fat deposition was identified as an independent risk factor for glucose metabolism disorders : patients with muscle fat≥42. 2% had a 2. 9 times risk of glucose me- tabolism abnormalities compared to those with muscle fat < 42. 2% .
Conclusion:With the occurrence of glucose metabolism disorders , muscle fat and iron deposition gradually increase in elderly obese patients . Muscle fat depo- sition is an independent risk factor for predicting glucose metabolism abnormalities in elderly obese patients .
- Full text:2026030512510698137肌肉脂肪及铁沉积与老年肥胖患者糖代谢的关系_聂浩.pdf
