The interconnected relationship between mitochondrial autophagy and ferroptosis in polycystic ovary syndrome
10.19405/j.cnki.issn1000-1492.2025.06.025
- Author:
Qi Zhao
1
;
Ping Chen
1
;
Liping Yang
2
;
Jianhua Sun
3
Author Information
1. Dept of Obstetrics and Gynecology , The First Afiliated Hospital of Henan University of Traditional Chinese Medicine , Zhengzhou 450000
2. Dept of Integrated Traditional Chinese and Western Medicine , School of Traditional Chinese Medicine , Henan University of Chinese Medicine , Zhengzhou 450046
3. Dept of Obstetrics and Gynecology , The First Afiliated Hospital of Henan University of Traditional Chinese Medicine , Zhengzhou 450000; Dept of Obstetrics and Gynecology Teaching and Research , Integrated Traditional Chinese and Western Medicine , First Clinical Medical College , Henan University of Chinese Medicine , Zhengzhou 450046
- Publication Type:Review
- Keywords:
polycystic ovary syndrome;
mitochondrial autophagy;
ferroptosis;
tandem mechanism;
granulosa cells
- From:
Acta Universitatis Medicinalis Anhui
2025;60(6):1149-1154
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Polycystic ovarian syndrome(PCOS) is a very common endocrine and reproductive disease. Its etiology and pathogenesis are complex and not yet fully clear. At present, the clinical treatment is mainly symptomatic. Studies have revealed that ferroptosis, as a new form of cell death, may play a key regulatory role in the occurrence and development of PCOS. In addition, there is an increase in autophagy/mitochondrial autophagy in PCOS patients, which may be closely related to the occurrence of ferroptosis. This review summarizes the pathogenesis of mitochondrial autophagy and ferroptosis in PCOS, and analyzes the interrelationship between mitochondrial autophagy and ferroptosis in granulosa cells, in order to provide new insights and potential therapeutic targets for the clinical treatment of PCOS.
- Full text:2026030409183048027多囊卵巢综合征中线粒体自噬与铁死亡之间串联关系_赵琦.pdf
