Follow-up study on hypertriglyceridemia after acute pancreatitis
10.19405/j.cnki.issn1000-1492.2025.12.018
- VernacularTitle:急性胰腺炎出院后高三酰甘油血症的随访研究
- Author:
Xinyue Zhao
1
;
Xiaolei Shi
1
;
Lianghao Hu
2
;
Guotao Lu
1
;
Jiajia Pan
3
Author Information
1. Dept of Gastroenterology, Afiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou 225012 ; Yangzhou Key Laboratory of Pancreatic Diseases , Yangzhou 225012
2. Dept of Gastroenterology, The First Afiliated Hospital of Naval Medical University, Shanghai 200433
3. Yangzhou Municipal Health Commission Intensive Care Medicine Laboratory, Yangzhou 225012
- Publication Type:Journal Article
- Keywords:
acute pancreatitis;
relapse;
lipid levels;
follow-up;
rick factors;
linear mixed model
- From:
Acta Universitatis Medicinalis Anhui
2025;60(12):2338-2345
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the temporal changes in lipid levels in patients following acute pancreatitis(AP) and explore the factors associated with post-AP serum triglyceride( TG) level changes.
Methods:Patients diag- nosed with AP were included in this study. Clinical data were collected retrospectively , and lipid profile data from follow-up visits after discharge were tracked. Kaplan-Meier(K-M) curves were used to stratify follow-up duration ,iodine content detection. Thyroid volume was measured using a fully digital ultrasound imaging system , and goiter prevalence was calculated.
Results:A total of 141 patients with 306 follow⁃up visits were included. Spearman correlation analysis showed a mild increase in lipid levels over time post⁃discharge : TG( r = 0. 159 , P = 0. 005) , total cholesterol(TC)( r = 0. 231 , P < 0. 000 1) , high⁃density lipoprotein cholesterol( HDL⁃C) ( r = 0. 181 , P = 0. 002) , and apolipoproteinA1 ( ApoA1) ( r = 0. 371 , P <0. 000 1) . In the univariate linear mixed model , male gender(β = 0. 160 ,P = 0. 007) , body mass index(BMI) (β= 0. 017 , P = 0. 007) , diabetes history(β = 0. 138 , P = 0. 030) , smoking history(β = 0. 166 ,P = 0. 004) , and recurrent AP(β = 0. 119 , P = 0. 029) were significantly associated with Lg(TG) levels (P < 0. 05) . In the multivariate model , BMI( β = 0. 019 , P = 0. 042) , smoking history ( β = 0. 155 , P = 0. 049 ) , and recurrent AP( β =0. 148 , P = 0. 032) remained significantly positively correlated with changes in Lg(TG) levels after AP , albeit with a low correlation strength (r < 0. 200) .
Conclusion:Lipid levels , including TG , TC , HDL⁃C and ApoA1 , tend to increase over time in AP patients after discharge , with this trend being more pronounced in those with hypertriglyceridemic acute pancreatitis. Post⁃AP TG levels are significantly influenced by BMI at the time of onset , smoking history and recurrent AP.
- Full text:2026030323341376696急性胰腺炎出院后高三酰甘油血症的随访研究_赵心悦.pdf
