Association study between mammalian sterile 20-like kinase 2 SNPs and colorectal cancer
10.19405/j.cnki.issn1000-1492.2025.12.009
- VernacularTitle:哺乳动物不育系 20 样激酶 2 基因多态性 与结直肠癌的关联分析
- Author:
Xingyu Wang
1
;
Licong Ma
2
;
Wenjie Dong
1
;
Fang Gao
3
;
Yanbin Jia
1
Author Information
1. School of Basic Medicine and Forensic Medicine , Baotou Medical College , Baotou 014040
2. School of Basic Medicine and Forensic Medicine , Baotou Medical College , Baotou 014040; Dept of Pathology, The Second Afiliated Hospital of Baotou Medical College ,Baotou 014030
3. School of Medical Technology and Anaesthesia , Baotou Medical College , Baotou 014040
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
mammalian sterile 20-like kinase 2;
single nucleotide polymorphism;
genotyping;
association study;
Hippo signaling pathway
- From:
Acta Universitatis Medicinalis Anhui
2025;60(12):2264-2272
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between mammalian sterile 20-like kinase 2(MST2) gene polymorphism and haplotype and the risk of colorectal cancer, rectal cancer, and colon cancer in the Han population in Baotou area by case-control association study.
Methods:A total of 390 patients with colorectal cancer diagnosed by pathology and 413 normal physical examination pop-ulation were collected, and 2 mL of peripheral blood was taken for subsequent gene genotyping. Single nucleotide polymorphisms(SNPs) of MST2 gene were screened according to the genetic polymorphism data of Chinese Han population provided by the NCBI-Hapmap database. Gene genotyping was performed by Taqman method. Logistic regression was used to calculate the association between each SNP and the risk of colorectal cancer, colon cancer, and rectal cancer under codominant, dominant, overdominant, and recessive genetic models.
Results:Five SNPs of MST2 gene were screened, namely rs11783149, rs10955176, rs7827435, rs4075986, rs3019295. Among them, SNP rs4075986 was associated with the risk of colorectal cancer. Compared with the rs4075986 GG+AA genotype, carrying the AG genotype [OR(95%CI)=2.473(1.844-3.316) could increase the risk of colorectal cancer. Compared with the rs4075986 GG genotype, carrying the AG+AA genotype [OR(95%CI)=2.475(1.844-3.323) could increase the risk of colorectal cancer. SNP rs4075986 and rs3019295 were associated with the risk of rectal cancer. Compared with the rs4075986 GG+AA genotype, carrying the AG genotype [OR(95%CI)=3.411(2.387-4.874)] could increase the risk of rectal cancer. Compared with the rs3019295 GG+AA genotype, carrying the AG genotype [OR(95%CI)=0.706(0.501-0.996)] could reduce the risk of rectal cancer. SNP rs11783149 and rs4075986 were associated with the risk of colon cancer. Compared with the rs11783149 CC genotype, carrying the TT [OR(95%CI)=10.883(1.186-99.862)] and CT [OR(95%CI)=1.665(1.036-2.675)] genotype could increase the risk of colon cancer, respectively. Compared with the rs4075986 GG genotype, the AG+AA genotype [OR(95%CI)=1.824(1.262-2.638)] could increase the risk of colon cancer.
Conclusion:MST2 gene SNP rs3019295 AG genotype may be protective factor for rectal cancer. SNP rs11783149 CT and TT genotypes maybe risk factors for colon cancer. SNP rs4075986 AG and AG+AA genotypes may be a common risk factors for colorectal cancer, rectal cancer and colon cancer.
- Full text:2026030322421606915哺乳动物不育系20样激酶2基因多态性与结直肠癌的关联分析_王兴宇.pdf
