Polystyrene microplastics induce oxidative stress and ferroptosis and cause myocardial damage in mice
10.19405/j.cnki.issn1000-1492.2025.06.005
- VernacularTitle:聚苯乙烯微塑料诱导氧化应激和铁死亡致小鼠心肌损伤作用
- Author:
Qi HUANG
1
;
Deyu ZHU
;
Xiao LIANG
;
Jinling WU
;
Wengui QIN
;
Ping MA
;
Yang WU
;
Cuiyu BAO
Author Information
1. 湖北科技学院药学院,咸宁 437100;湖北科技学院基础医学院环境相关疾病与健康重点实验室,咸宁 437100
- Publication Type:Journal Article
- Keywords:
polystyrene microplastics;
oxidative stress;
ferroptosis;
myocardial damage;
environmental contami-nants
- From:
Acta Universitatis Medicinalis Anhui
2025;60(6):1009-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of polystyrene microplastics(PS-MPs)on myocardial injury in mice and its molecular mechanism.Methods A total of 60 male C57BL/6 mice were randomly divided into normal sa-line group,0.1,1,10 mg/kg PS-MPs exposed group,and doxorubicin[5 mg/(kg·w)]group treated for 8 weeks.After treatment,we measured blood pressure,cardiac organ coefficient,cardiac histopathological changes,oxidative stress markers reactive oxygen species(ROS),malondialdehyde(MDA),glutathione(GSH),4-hydroxynonenal(4-HNE)and nuclear factor E2-related factor 2(Nrf2),serum centroid injury markers creatine kinase MB(CK-MB)and troponin(cTnT),ferroptosis marker recombinant glutathione peroxidase 4(GPX4),Recombinant solute carrier family 7(SLC7 A11)as well as ferrous ions(Fe2+).Results Compared with the neg-ative control group,vacuolation,inflammatory infiltration and collagen fiber deposition were evident in the hearts of mice after PS exposure.The levels of myocardial injury markers CK-MB and cTnT significantly increased.Cardiac organ coefficient decreased,blood pressure increased,oxidative stress markers and ferroptosis markers increased.Conclusion PS-MPs exposure can induce oxidative stress and activate ferroptosis pathway,resulting in myocardial injury in mice.
