Polystyrene microplastics induce oxidative stress and ferroptosis and cause myocardial damage in mice
- Author:
Qi Huang
1
;
Deyu Zhu
1
;
Xiao Liang
2
;
Jinling Wu
3
;
Wengui Qin
3
;
Ping Ma
3
;
Yang Wu
3
;
Cuiyu Bao
3
Author Information
1. School of Pharmacy, School of Basic Medicine , Hubei University of Science and Technology , Xianning 437100 ; Key Laboratory of Environmental Related Diseases and One Health , School of Basic Medicine , Hubei University of Science and Technology , Xianning 437100
2. Key Laboratory of Environmental Related Diseases and One Health , School of Basic Medicine , Hubei University of Science and Technology , Xianning 437100 ; Fankou Branch of Ezhou Central Hospital , Ezhou 436001
3. Key Laboratory of Environmental Related Diseases and One Health , School of Basic Medicine , Hubei University of Science and Technology , Xianning 437100
- Publication Type:Journal Article
- Keywords:
polystyrene microplastics;
oxidative stress;
ferroptosis;
myocardial damage;
environmental contaminants
- From:
Acta Universitatis Medicinalis Anhui
2025;60(6):1009-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the effect of polystyrene microplastics(PS-MPs) on myocardial injury in mice and its molecular mechanism.
Methods: A total of 60 male C57BL/6 mice were randomly divided into normal saline group, 0.1, 1, 10 mg/kg PS-MPs exposed group, and doxorubicin [5 mg/(kg·w)] group treated for 8 weeks. After treatment, we measured blood pressure, cardiac organ coefficient, cardiac histopathological changes, oxidative stress markers reactive oxygen species(ROS), malondialdehyde(MDA), glutathione(GSH), 4-hydroxynonenal(4-HNE) and nuclear factor E2-related factor 2(Nrf2), serum centroid injury markers creatine kinase MB(CK-MB) and troponin(cTnT), ferroptosis marker recombinant glutathione peroxidase 4(GPX4), Recombinant solute carrier family 7(SLC7A11) as well as ferrous ions(Fe2+).
Results :Compared with the negative control group, vacuolation, inflammatory infiltration and collagen fiber deposition were evident in the hearts of mice after PS exposure. The levels of myocardial injury markers CK-MB and cTnT significantly increased. Cardiac organ coefficient decreased, blood pressure increased, oxidative stress markers and ferroptosis markers increased.
Conclusion :PS-MPs exposure can induce oxidative stress and activate ferroptosis pathway, resulting in myocardial injury in mice.
- Full text:2026030216001528373聚苯乙烯微塑料诱导氧化应激和铁死亡致小鼠心肌损伤作用_黄琪.pdf
