The outcomes of induction treatments in childhood acute lymphoblastic leukemia at Children Hospital, Vientiane Capital, Lao PDR
- Author:
Thatsadaphone Khounnorath
1
;
Patcharee Komvilaisak
2
;
Bounpalisone Souvanlasy
3
;
Sourideth Sengchanh
1
Author Information
- Collective Name:LMJ
- Publication Type:Journal Article
- Keywords: Acute lymphoblastic leukemia, Peripheral blood smear, Chemotherapy, Children Hospital
- From:Lao Medical Journal 2023;14(14):86-92
- CountryLao People's Democratic Republic
- Language:English
-
Abstract:
Background: :Cancer is one of the leading causes of death in children. The incidence of cancer in children under the age of 15 year varies worldwide. Despite significant advances in the treatment and early detection, cancer is the second major cause of child mortality in developed world. In some developed countries such as Australia, Ireland, Switzerland and the United States, the incidence of childhood cancer has been estimated at 140 - 160 per 1 million children.
Objectives: :To determine the outcomes of induction treatment in childhood acute lymphoblastic leukemia at Children Hospital, Vientiane Capital, Lao PDR.
Methodology:: A prospective descriptive study at Hematology - Oncology department, Children hospital, in Vientiane Capital, Laos.From December 2021 to November 2022. The include criteria was the newly acute lymphoblastic leukemia who received chemotherapy treatment during induction phase. The descriptive statistic was analyzed with SPSS version 26 and reported by table, chart with frequency
Results: :A total participants 36 newly acute lymphoblastic leukemia including the male was higher the female, the clinical profile showed fever and pale were most common, during the induction were including the complication of specific treatment and supportive treatment. Seven (19.4%) patients died due to infection the pathogen of hemoculture were acetobacter, klebsiella pneumonia, pseudomonas aeruginosa and ESBL, bleeding and tumor lysis syndrome during the course of induction therapy. After induction therapy twenty-two (61.1%) patients went into the complete remission (<5%blast cells in bone marrow), five patients (13.9%) was not in remission (>5%blast cells in the bone marrow).Seven (19.4%) patients died and 2 patients were refuse of treatment including the problem of financial and family.
Conclusion: :The rate of complete remission of induction therapy and death during induction therapy of the outcome in acute lymphoblastic leukemia was high, the male of remission is higher than female and the most classification of risk group was high risk group. The feature of clinical acute lymphoblastic leukemia paediatric was fever and pallor. The majority cause of death is infection. - Full text:2026030212500144869ບົດທີ_10. Dr. Thatsadaphone_(LMJ_14).pdf
