Serological Response to Hepatitis-B Vaccine in HIV Infected Children, Mahosot Hospital, Vientiane Capital
- Author:
Sengdaophone Simalang
1
;
Pope Kosalaraksa
2
;
Mayfong Mayxay
3
;
Bandith Soumphonphakdy
4
Author Information
- Collective Name:LMJ
- Publication Type:Journal Article
- Keywords: anti-HBs, HIV infected children, HBV booster, Lao PDR.
- From:Lao Medical Journal 2023;14(14):79-85
- CountryLao People's Democratic Republic
- Language:English
-
Abstract:
Rationale and Background: :Hepatitis B virus (HBV) vaccine has been developed in early 1980s and shown good efficacy. However, children with HIV infection had poor immune response to many kinds of vaccines.
Objectives: :To assess the persistence of vaccine immunity against HBV after the primary vaccination in infancy and the response to revaccination in HIV-infected children in Mahosot hospital.
Methodology: :This study was prospectively conducted in HIV-infected children at Mahosot hospital from September 2021 to August 2022. Seventy HIV-infected children were enrolled. Inform consent was performed before starting the study. Anti-HBs was checked, if anti-HBs≥10 mIU/mL, the subjects would not receive booster dose for Hepatitis B vaccine. If anti-HBs<10 mIU/mL, the patient will receive one booster dose and checked for anti-HBs 4-8 weeks after. If anti-HBs was still<10 mIU/mL, another 2 booster doses will be given and anti-HBs is checked 4-8 weeks after.
Results: :We enrolled 70 HIV-infected children, most of them were older than 10 years (median=12.5). The mean age at diagnosis of HIV was 2.9 years. Sixty-seven (95.7%) had anti-HBs titer <10 mIU/mL at baseline (first visit). After the first booster, 18(26.9%) had anti-HBs titer ≥10 mIU/mL. In 49 subjects who had anti-HBs <10 mIU/mL after the first dose and received another 2 booster HBV doses, 10(20.4%) still had anti-HBs <10 mIU/mL. Anti-HBs titers at baseline, after 1st booster and after 3rd booster were5.2, 8.2, and 30mIU/mL, respectively.
Conclusion: :In HIV-infected children who received primary series of HBV vaccine, almost all of them (95.7%) had anti-HBs lower than seroprotective level (<10 mIU/mL). Only one fourth achieved seroprotective level after the 1st booster but 79.6% achieved seroprotective level after the 3rd booster. The results suggested that HIV-infected children should receive 3 doses of HBV revaccination. - Full text:2026030212455096232ບົດທີ_09. Dr. Sengdaophone_manuscript (LMJ_14)_edit.pdf
