Research progress on the correlation between bone marrow microenvironment remodeling and chemotherapy resistance in acute myeloid leukemia
10.13200/j.cnki.cjb.004658
- VernacularTitle:骨髓微环境转换与急性髓系白血病化疗耐药相关性的研究进展
- Author:
Haoming QU
1
Author Information
1. School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
Acute myeloid leukemia(AML);
Bone marrow microenvironment(BMM);
Inflammatory microenvironment;
Immune microenvironment;
Metabolic reprogramming
- From:
Chinese Journal of Biologicals
2026;39(02):237-242+250
- CountryChina
- Language:Chinese
-
Abstract:
As a malignant tumor with high invasiveness and a tendency to recur, the pathogenesis of acute myeloid leukemia(AML) is closely related to the malignant transformation of the bone marrow microenvironment(BMM). AML cells promote the transformation of inflammatory, immune, and metabolic microenvironments through their interaction with the BMM,resulting in the normal hematopoietic microenvironment being converted into a malignant one that favors the survival and development of AML cells. The restructured BMM, in turn, facilitates the acquisition of drug resistance by AML cells, thus forming a malignant dynamic cycle. The key to breaking this cycle lies in:(1) targeting inflammatory factors[such as the interleukin-6(IL-6)/JAK/STAT pathway];(2) inhibiting immune checkpoint molecules[such as programmed death ligand-1(PD-L1)]or immune suppressive cells;(3) blocking metabolic reprogramming(such as aerobic glycolysis, mitochondrial transfer). Based on this, this paper reviews the bidirectional regulatory role of the BMM at relevant levels during the development of AML, with the aim of discovering new ideas and potential research targets in therapeutic strategies targeting the transformation mechanisms of the BMM and interventions for AML resistance.
