Regulatory effects of lactate/lactylation modification on tumor-associated macrophages and its research progress in tumor therapy
10.13200/j.cnki.cjb.004654
- VernacularTitle:乳酸/乳酸化修饰对肿瘤相关巨噬细胞的调控作用及其在肿瘤治疗中的研究进展
- Author:
Pengfei LEI
1
Author Information
1. School of Public Health, Gansu University of Traditional Chinese Medicine, Research Center of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
Lactate;
Lactylation;
Tumor-associated macrophage(TAM);
Tumor microenvironment(TME)
- From:
Chinese Journal of Biologicals
2026;39(02):229-236
- CountryChina
- Language:Chinese
-
Abstract:
Lactate, as a key metabolic product of glycolysis, directly enhances the survival, proliferation, and migration of tumor cells by mediating metabolic reprogramming, signal transduction, and epigenetic modifications. Lactylation is a posttranslational modification process induced by lactate, which regulates cellular signaling, gene expression, and protein function, thereby influencing tumor progression. Elevated lactate levels are a key driving factor for lactylation. Tumor-associated macrophage(TAM) in the tumor microenvironment(TME) promote tumor growth, metastasis, and immune evasion. Furthermore, lactate drives polarization of TAM through the lactylation modification mechanism, promotes angiogenesis, and suppresses immune responses, creating a favorable survival environment for tumors. Therefore, this review summarizes the recent research on the regulatory effects of lactate/lactylation on TAM function and its role in tumor treatment, aiming to provide reference for tumor research and treatment.
