Research progress on the tumor microenvironment of liver cancer
10.12206/j.issn.2097-2024.202504126
- VernacularTitle:肝癌肿瘤微环境的研究进展
- Author:
Tianhao SONG
1
;
Weiheng XU
2
;
Yan WANG
2
;
Li CHEN
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
liver cancer;
microenvironment;
hepatic stellate cells;
immune cells;
platelets;
extracellular matrix
- From:
Journal of Pharmaceutical Practice and Service
2026;44(2):65-70
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer, one of the most common primary malignancies in humans, is a malignant tumor characterized by multifactorial induction, polygenic involvement, and intricate molecular mechanisms. This disease is characterized by its treatment challenges and poor prognosis, which are closely related to its unique tumor microenvironment composition. The tumor microenvironment of liver cancer is a dynamic ecosystem composed of heterogeneous cellular populations, soluble cytokines, and remodeled extracellular matrix. In recent years, significant progress has been made in the study of the tumor microenvironment of liver cancer, revealed an important role in the occurrence, development, and treatment of liver cancer. The key regulatory elements of the tumor microenvironment in liver cancer were systematically summarized, such as activation of hepatic stellate cells, dysfunction of immune cells, abnormalities of platelet, and remodeling of the extracellular matrix, which provided theoretical foundations for prevention and treatment strategies against liver cancer.
